XMEA: A New Hybrid Diamond Multielectrode Array for the In Situ Assessment of the Radiation Dose Enhancement by Nanoparticles

Full text
Author(s):	Nicolucci, Patricia ; Gambaro, Guilherme ; Silva, Kyssylla Monnyelle Araujo ; Lima, Iara Souza ; Baffa, Oswaldo ; Pasquarelli, Alberto Total Authors: 6
Document type:	Journal article
Source:	SENSORS; v. 24, n. 8, p. 15-pg., 2024-04-01.
Abstract
This work presents a novel multielectrode array (MEA) to quantitatively assess the dose enhancement factor (DEF) produced in a medium by embedded nanoparticles. The MEA has 16 nanocrystalline diamond electrodes (in a cell-culture well), and a single-crystal diamond divided into four quadrants for X-ray dosimetry. DEF was assessed in water solutions with up to a 1000 mu g/mL concentration of silver, platinum, and gold nanoparticles. The X-ray detectors showed a linear response to radiation dose (r2 >= 0.9999). Overall, platinum and gold nanoparticles produced a dose enhancement in the medium (maximum of 1.9 and 3.1, respectively), while silver nanoparticles produced a shielding effect (maximum of 37%), lowering the dose in the medium. This work shows that the novel MEA can be a useful tool in the quantitative assessment of radiation dose enhancement due to nanoparticles. Together with its suitability for cells' exocytosis studies, it proves to be a highly versatile device for several applications. (AU)

FAPESP's process:	18/05982-0 - R&D&I in radiation metrology in the health area
Grantee:	Linda Viola Ehlin Caldas
Support Opportunities:	Research Projects - Thematic Grants