| Full text | |
| Author(s): |
Vega, Kimberly Benedetti
;
de Oliveira, Andre Luiz Carvalho
;
Konig, Burkhard
;
Paixao, Marcio Weber
Total Authors: 4
|
| Document type: | Journal article |
| Source: | ORGANIC LETTERS; v. 26, n. 4, p. 6-pg., 2024-01-22. |
| Abstract | |
beta-Amidated carboxylic acids, or succinamic acid derivatives, constitute a valuable chemical scaffold with broad applications in pharmaceuticals, agrochemicals, and polymer sciences. Herein, we report a redox-neutral multicomponent reaction for the synthesis of succinamic acid derivatives in good yields. This protocol involves styrene, CO(2 )and 1,4-carbamoyl-dihydropyridine as radical precursors. The method exhibits a broad substrate scope under mild reaction conditions, including late-stage functionalization. Moreover, by employing (CO2)-C-13, the method enables the synthesis of labeled 1,2-dicarboxylic compounds. (AU) | |
| FAPESP's process: | 23/08283-3 - Multicomponent synthesis of alpha-carboxy-beta-alkylated phosphonates mediated by visible light using CO2 and RBF3K |
| Grantee: | André Luiz Carvalho de Oliveira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 23/05334-6 - Chasing sustainability: photoinduced synthesis of dicarboxylic systems from alkenes via CO2 or a CO2/carbamoyl-radical cocktail |
| Grantee: | Kimberly Benedetti Vega |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 21/06099-5 - Development of new photochemical methodologies for the synthesis of small molecule and biomolecule modifications |
| Grantee: | Márcio Weber Paixão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/01354-7 - Photocatalysis applied to difunctionalization of alkenes via CO2 incorporation: multicomponent synthesis of ²-sulfonil and ±- (2-sulfenyl-indolyl) -carboxylic acids |
| Grantee: | Kimberly Benedetti Vega |
| Support Opportunities: | Scholarships in Brazil - Doctorate |