Unveiling microtubule dynamics in lung cancer: Recent findings and prospects for drug delivery and treatment

Author(s):Show less -

Yukuyama, Megumi Nishitani ; de Souza, Aline ; Bazan Henostroza, Mirla Anali ; Barros de Araujo, Gabriel Lima ; Lobenberg, Raimar ; Faria, Rafael de Oliveira ; de Souza, Gabriel Batista ; Ferreira Guimaraes, Lara Mendes ; Lameu, Claudiana ; Folchini, Beatriz Rabelo ; Peroni, Camilla Midori ; Oliveira, Isabela Fernandes ; Saito Miyagi, Mariana Yasue ; Bou-Chacra, Adia Araci

• Document type: Journal article
• Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 89, p. 14-pg., 2023-10-12.

Abstract

Microtubules are dynamic proteins that play crucial roles in the normal functions of cells. Chromosome missegregation driven by microtubules during cell division can lead to several diseases, including cancer. Among them, lung cancer is one of the leading causes of tumor mortality worldwide, and presents several limitations including early prognosis and currently available treatments. This review revisited the role of several features of microtubules in lung cancer, which include microtubule isotypes, bioelectrical function of microtubules, kinetochoreand mitochondrial-microtubule interactions, as well as ciliogenesis in tumor development and progression. These findings support recent discoveries of biomarkers and nanotechnology-based microtubule targeting drugs for development of early prognosis or alternative treatments. Thus, this manuscript aims to deliver new insights and deepen understanding of these intriguing interactions of microtubules and lung cancer, which will serve as a basis for the future development of new alternatives of delivery systems to overcome the limitations of current treatments. (AU)

• FAPESP's process: 16/26189-0 - Multi-User Equipment approved in grant: tissue FAXS plus
• Grantee: Claudiana Lameu
• Support Opportunities: Multi-user Equipment Program
• FAPESP's process: 22/02193-0 - Antiparasitic drug repositioning for Cancer treatment using nanostructured drug delivery systems
• Grantee: Nádia Araci Bou-Chacra
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/22713-2 - Study of Flubendazole repositioning for the treatment of lung cancer and MENINGOENCEFALITE employing oral lipid nanosystem
• Grantee: Megumi Nishitani Yukuyama
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 19/04998-2 - Nanocrystalline and amorphous solid dispersions formulations for improvement of antitumor therapies
• Grantee: Gabriel Lima Barros de Araujo
• Support Opportunities: Regular Research Grants