Myeloproliferative Neoplasms Transcriptome Reveals Pro-Inflammatory Signature and Enrichment in Peripheral Blood Monocyte-Related Genes

Author(s)

Bassan, Vitor Leonardo ; de Freitas Martins Felicio, Rafaela ; de Farias, Kelen Cristina Ribeiro Malmegrim ; de Castro, Fabiola Attie

• Document type: Journal article
• Source: CANCER INVESTIGATION; v. 42, n. 7, p. 14-pg., 2024-07-02.

Abstract

Myeloproliferative neoplasms (MPN) are hematological diseases associated with genetic driver mutations in the JAK2, CALR, and MPL genes and exacerbated oncoinflammatory status. Analyzing public microarray data from polycythemia vera (n = 41), essential thrombocythemia (n = 21), and primary myelofibrosis (n = 9) patients' peripheral blood by in silico approaches, we found that pro-inflammatory and monocyte-related genes were differentially expressed in MPN patients' transcriptome. Genes related to cell activation, secretion of pro-inflammatory and pro-angiogenic mediators, activation of neutrophils and platelets, coagulation, and interferon pathway were upregulated in monocytes compared to controls. Together, our results suggest that molecular alterations in monocytes may contribute to oncoinflammation in MPN. (AU)

• FAPESP's process: 19/18013-8 - Immunophenotypic and molecular characterization of monocyte subpopulations in myeloproliferative neoplasms
• Grantee: Vitor Leonardo Bassan
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
• Grantee: Dimas Tadeu Covas
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/19714-7 - Bone Marrow Mesenchymal Stromal Cells deregulation effect on BCR-ABL1-Myeloproliferative Neoplasms pathophysiology and progression
• Grantee: Fabíola Attié de Castro
• Support Opportunities: Regular Research Grants