| Full text | |
| Author(s): Show less - |
Buralli, Rafael Junqueira
;
da Silva, Zilda Pereira
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Alencar, Gizelton Pereira
;
Figueiredo, Gerusa Maria
;
Hoshida, Mara Sandra
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Luna, Expedito J. A.
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Pastro, Luciana Duzolina Manfre
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dos Santos, Osmara Alves
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Marques, Lays Janaina Prazeres
;
Zerbinati, Rodrigo Melim
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Galisteo Junior, Andres Jimenez
;
Andrade Junior, Heitor de
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Machado, Clarisse M.
;
Meireles, Luciana Regina
;
Schultz, Regina
;
Rodrigues, Laura Cunha
;
Francisco, Rossana Pulcineli Vieira
;
Novaes, Hillegonda Maria Dutilh
;
de Almeida, Marcia Furquim
;
Gouveia, Nelson
Total Authors: 20
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| Document type: | Journal article |
| Source: | BMJ OPEN; v. 14, n. 6, p. 10-pg., 2024-06-01. |
| Abstract | |
Stillbirth is a fundamental component of childhood mortality, but its causes are still insufficiently understood. This study aims to explore stillbirth risk factors by using a multidisciplinary approach to stimulate public policies and protocols to prevent stillbirth, improve maternal care and support bereaved families.Methods and analysis In this case-control study with stillbirths and live births in 14 public hospitals in S & atilde;o Paulo, mothers are interviewed at hospitals after delivery, and hospital records and prenatal care registries are reviewed. Maternal and umbilical cord blood samples and placentas are collected to analyse angiogenesis and infection biomarkers, and the placenta's anatomopathological exam. Air pollutant exposure is estimated through the participant's residence and work addresses. Traditional and non-invasive autopsies by image-guided histopathology are conducted in a subset of stillbirths. Subsample mothers of cases are interviewed at home 2 months after delivery on how they were dealing with grief. Information contained in the official prenatal care registries of cases and controls is being compiled. Hospital managers are interviewed about the care offered to stillbirth mothers. Data analysis will identify the main risk factors for stillbirth, investigate their interrelations, and evaluate health services care and support for bereaved families. We hope this project will contribute to the understanding of stillbirth's risk factors and related health services in Brazil, providing new knowledge about this central public health problem, contributing to the improvement of public policies and prenatal and puerperal care, helping to prevent stillbirths and improve the healthcare and support for bereaved families.Ethics and dissemination This study protocol was approved by the Ethics Committee of the Municipal Health Secretary (process no 16509319.0.3012.5551) and of the Hospital das Cl & iacute;nicas, Faculdade de Medicina, Universidade de S & atilde;o Paulo (process no 16509319.0.0000.0068). Results will be communicated to the study participants, policy-makers and the scientific community. (AU) | |
| FAPESP's process: | 20/05458-9 - Prenatal and obstetric care public policies and fetal death |
| Grantee: | Osmara Alves Viana |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 22/16153-0 - Air pollution and fetal deaths |
| Grantee: | Rafael Junqueira Buralli |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/07765-0 - Fetal deaths: challenges for knowledge and intervention |
| Grantee: | Nelson da Cruz Gouveia |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/13271-1 - Factors associated with fetal vulnerability and to fetal death |
| Grantee: | Lays Janaina Prazeres Marques |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |