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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neonatal inflammatory pain increases hippocampal neurogenesis in rat pups

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Author(s):
Leslie, Ana Teresa F. S. [1] ; Akers, Katherine G. [2] ; Martinez-Canabal, Alonso [2, 3] ; de Araujo Mello, Luis Eugenio [4] ; Covolan, Luciene [4] ; Guinsburg, Ruth [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo - Brazil
[2] Hosp Sick Children, Toronto, ON M5G 1X8 - Canada
[3] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A1 - Canada
[4] Univ Fed Sao Paulo, Dept Fisiol, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Neuroscience Letters; v. 501, n. 2, p. 78-82, AUG 26 2011.
Web of Science Citations: 24
Abstract

Preterm infants undergo several painful procedures during their stay in neonatal intensive care units. Previous studies suggest that early painful experiences may have an impact on brain development. Here, we used an animal model to investigate the effect of neonatal pain on the generation of new neurons in the dentate gyrus region of the hippocampus. Rat pups received intraplantar injections of complete Freund's adjuvant (CFA), a painful inflammatory agent, on either PI or P8 and were sacrificed on P22. We found that rat pups injected with CFA on P8 had more BrdU-labeled cells and a higher density of cells expressing doublecortin (DCX) in the subgranular zone of the dentate gyrus. No change in BrdU-labeling or DCX expression was observed in pups injected with CFA on P1. These findings indicate that neonatal pain can increase hippocampal neurogenesis, suggesting that early painful experiences may shape brain development and thereby influence behavioral outcome. (C) 2011 Elsevier Ireland Ltd. All rights reserved. (AU)