Mantle Cell Lymphoma in the Oral Cavity: Exploring the Differential Microscopic Diagnosis of a Rare Case

Author(s)

Goncalves, Moises Willian Aparecido ; Lavareze, Luccas ; Chone, Carlos Takahiro ; Egal, Erika Said Abu ; Altemani, Albina ; Mariano, Fernanda Viviane ; de Freitas, Leandro Luiz Lopes

• Document type: Journal article
• Source: INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY; v. N/A, p. 4-pg., 2024-07-03.

Abstract

Mantle cell lymphoma (MCL) is a rare subtype of B-cell non-Hodgkin's lymphoma (NHL), which generally has an aggressive course. Its pathophysiology seems to be related with the malignant transformation of B-cell mantle zone lymphocytes due to the CCND1 rearrangement. The occurrence of MCL in the oral cavity is especially rare. In this report, we present an exceptional case of oral MCL diagnosed in the palate in a 56-year-old male patient, highlighting its distinct morphological and immunohistochemical features that may assist in the accurate diagnosis. (AU)

• FAPESP's process: 22/11861-6 - Comparative analysis of Adenoid Cystic Carcinoma exome in xenograft model with and without entinostat and cisplatin therapy
• Grantee: Luccas Lavareze dos Reis
• Support Opportunities: Scholarships in Brazil - Doctorate