| Full text | |
| Author(s): |
Sbragia, Lourenco
;
Gualberto, Igor Jose Nogueira
;
Xia, Jason
;
Gadde, Rahul
;
Saulsbery, Angela
;
Hameedi, Sophia
;
Dalto, Ana Laura Ferreira Marsico
;
Olutoye, Oluyinka O.
Total Authors: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF SURGICAL RESEARCH; v. 303, p. 15-pg., 2024-10-21. |
| Abstract | |
Introduction: Necrotizing enterocolitis (NEC) is a severe inflammatory disease of the gastrointestinal tract and one of the most common life-threatening emergencies affecting newborns. Intestinal fatty acid-binding protein (I-FABP) has been used as a possible marker of intestinal damage in NEC. We aimed to carry out a scoping review of all publications that explore the role of I-FABP in NEC to inspire new research into the potential utility of I-FABP as a marker of NEC. Methods: We searched for relevant publications using the keywords "necrotizing enterocolitis," "intestinal fatty acid binding protein," "NEC," and "I-FABP" in the National Library of Medicine (PubMed/MEDLINE), Embase, SCOPUS, and Web of Science. Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews was used for reporting findings. Results: We identified 61 relevant articles, which we divided into clinical (n = 47) and experimental (n = 14) groups. Conclusions: I-FABP is a promising marker of NEC, especially for NEC stage 2 and 3. Urinary I-FABP follows the same patterns as serum and plasma I-FABP. The definitive roles of IFABP in early diagnosis of NEC, differential diagnosis in breast feeding, alimentary intolerance, and screening of surgical NEC need clarification and remain a challenge to investigators. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU) | |
| FAPESP's process: | 22/12021-1 - The effect of inhaled nitric oxide on intestinal perfusion in the neonatal piglet |
| Grantee: | Lourenço Sbragia Neto |
| Support Opportunities: | Scholarships abroad - Research |