| Full text | |
| Author(s): |
Ribeiro, Henrique Caracho
;
Zandonadi, Flavia da Silva
;
Sussulini, Alessandra
Total Authors: 3
|
| Document type: | Journal article |
| Source: | EXPERT REVIEW OF PROTEOMICS; v. 20, n. 11, p. 14-pg., 2023-10-18. |
| Abstract | |
Introduction:<br />Bipolar disorder (BD) is a complex psychiatric disease characterized by alternating mood episodes. As for any other psychiatric illness, currently there is no biochemical test that is able to support diagnosis or therapeutic decisions for BD. In this context, the discovery and validation of biomarkers are interesting strategies that can be achieved through proteomics and metabolomics. Areas covered:In this descriptive review, a literature search including original articles and systematic reviews published in the last decade was performed with the objective to discuss the results of BD proteomic and metabolomic profiling analyses and indicate proteins and metabolites (or metabolic pathways) with potential clinical value. Expert opinion:<br />A large number of proteins and metabolites have been reported as potential BD biomarkers; however, most studies do not reach biomarker validation stages. An effort from the scientific community should be directed toward the validation of biomarkers and the development of simplified bioanalytical techniques or protocols to determine them in biological samples, in order to translate proteomic and metabolomic findings into clinical routine assays. (AU) | |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 23/01800-2 - Exploring the potential of cannabis in the treatment of neurodegenerative diseases |
| Grantee: | Alessandra Sussulini |
| Support Opportunities: | Regular Research Grants |