| Full text | |
| Author(s): |
Humberto, Janaina Silva Martins
;
Saia, Rafael Simone
;
Costa, Luis Henrique Angenendt
;
Rocha, Maria Jose Alves
;
Motta, Ana Carolina Fragoso
Total Authors: 5
|
| Document type: | Journal article |
| Source: | ODOVTOS INTERNATIONAL JOURNAL OF DENTAL SCIENCES; v. 26, n. 2, p. 13-pg., 2024-05-01. |
| Abstract | |
This study aimed to determine salivary concentrations of interleukin (IL)-1 beta, IL-2, IL-10, IL23, transforming growth factor (TGF)- beta, tumor necrosis factor (TNF)- alpha, nitrate (a by-product of nitric oxide oxidation), and cortisol in patients with oral lichen planus (OLP). Twenty patients diagnosed with OLP and 20 sex-matched healthy volunteers (HV) were included in this cross-sectional study. Unstimulated whole saliva was collected in the morning. Salivary cytokine and cortisol concentrations were determined by enzyme-linked immunosorbent assays (ELISA). Nitrate was measured in a nitric oxide analyzer. We found higher salivary concentrations of IL-2 (p<0.003), IL-23 ( p<0.04), and TGF- beta (p=0.05) in patients with OLP compared to HV. No significant differences were found in salivary levels of TNF- alpha, IL-1 beta, or IL-10. Nitrate concentrations were markedly increased in OLP patients (1,227.0 +/- 738.8 mu M/mg total protein) when compared to HV (261.6 +/- 166.8 mu M/mg; p<0.0001). Salivary cortisol levels were also higher in OLP patients (2.79 +/- 1.39 vs. 1.94 +/- 1.21 ng/mg; p<0.048). The markedly increased salivary levels of nitric oxide in patients with OLP suggest a relationship of this molecule with the cell death and tissue damage observed in these lesions. (AU) | |
| FAPESP's process: | 13/15214-6 - Role of cholecystokinin in intestinal epithelial barrier dysfunction induced by systemic inflammation |
| Grantee: | Rafael Simone Saia |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/22183-5 - Neuroimunoendócrinos aspects in patients with Oral Lichen Planus |
| Grantee: | Karla Karine Duarte Maia |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 14/11883-3 - Clinical, histopathological and immunopathological profile of patients presenting oral lichen planus |
| Grantee: | Ana Carolina Fragoso Motta |
| Support Opportunities: | Regular Research Grants |