| Full text | |
| Author(s): |
Caldas, Gabriel Rocha
;
do Amaral, Lilian
;
Rodrigues, Debora Munhoz
;
de Miranda, Aline Mayrink
;
dos Santos, Neife Aparecida Guinaim
;
Rocha, Leandro Machado
;
Parreira, Renato Luis Tame
;
dos Santos, Antonio Cardozo
;
Bastos, Jairo Kenupp
Total Authors: 9
|
| Document type: | Journal article |
| Source: | CHEMISTRY & BIODIVERSITY; v. 20, n. 12, p. 10-pg., 2023-11-27. |
| Abstract | |
Artepillin C is the most studied compound in Brazilian Green Propolis and, along with its acetylated derivative, displays neurotrophic activity on PC12 cells. Specific inhibitors of the trkA receptor (K252a), PI3K/Akt (LY294002), and MAPK/ERK (U0126) signaling pathways were used to investigate the neurotrophic mechanism. The expression of proteins involved in axonal and synaptic plasticity (GAP-43 and Synapsin I) was assessed by western blotting. Additionally, physicochemical properties, pharmacokinetics, and drug-likeness were evaluated by the SwissADME web tool. Both compounds induced neurite outgrowth by activating the NGF-signaling pathways but through different neuronal proteins. Furthermore, in silico analyses showed interesting physicochemical and pharmacokinetic properties of these compounds. Therefore, these compounds could play an important role in axonal and synaptic plasticity and should be further investigated. image (AU) | |
| FAPESP's process: | 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector |
| Grantee: | Jairo Kenupp Bastos |
| Support Opportunities: | Research Projects - Thematic Grants |