| Full text | |
| Author(s): |
Xavier, Gabriela
;
Mauer, Jessica
;
Ota, Vanessa K.
;
Santoro, Marcos L.
;
Belangero, Sintia I.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | JOURNAL OF PSYCHIATRIC RESEARCH; v. 176, p. 10-pg., 2024-06-12. |
| Abstract | |
Schizophrenia (SCZ) is a severe psychiatric disorder with unclear pathophysiology. Moreover, there is no specific biological marker to help clinicians to define a diagnosis, and medication is decided according to the psychiatrist's experience. In this scenario, microRNAs (miRNAs), which are small noncoding RNA molecules that regulate several genes, emerge as potential peripheral biomarkers to help not only the evaluation of the disease state but also the treatment response. Here, we systematically reviewed indexed literature and evaluated followup studies investigating the changes in miRNA expression due to antipsychotic treatment. We also assessed target genes and performed pathway enrichment analysis of miRNAs listed in this systematic review. A total of 11 studies were selected according to research criteria, and we observed that 28 miRNAs play a relevant role in schizophrenia pathogenesis or response to antipsychotic treatment, seven of those of extreme interest as possible biomarkers either for condition or treatment. Predicted targets of the miRNAs reviewed here were previously associated with schizophrenia in genome-wide studies, and pathway analysis showed enrichment for genes related to neural processes. With this review, we expect to highlight the importance of miRNAs in schizophrenia pathogenesis and its treatment and point out interesting miRNAs to future studies. (AU) | |
| FAPESP's process: | 20/02247-7 - Evaluation of differential extracellular vesicule miRNA expression associated with the emergence of psychiatric symptoms in adolescents |
| Grantee: | Jessica Honorato Mauer |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 16/19462-2 - MiRNA role in schizophrenia: from genome until protein |
| Grantee: | Gabriela Xavier |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 23/05560-6 - Genetic and epigenetic approaches as predictive models in mental disorders |
| Grantee: | Marcos Leite Santoro |
| Support Opportunities: | Research Grants - Young Investigators Grants |