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Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in Sporothrix brasiliensis Infection: Case Report

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Author(s):
Veasey, John Verrinder ; Reis, Ana Paula Carvalho ; Celestrino, Giovanna Azevedo ; Silva, Camila Estacia ; Santos, Eduarda Souza ; Mendes, Denise Polizel ; Andrade, Tania Sueli ; Bonfietti, Lucas Xavier ; Benard, Gil ; Sousa, Maria Gloria Texeira
Total Authors: 10
Document type: Journal article
Source: MICROORGANISMS; v. 12, n. 11, p. 5-pg., 2024-11-01.
Abstract

Sporotrichosis is a subcutaneous infection caused by fungi from the genus Sporothrix, among which Sporothrix brasiliensis displays high virulence and transmissibility. So far, classical antifungal agents have been efficient against S. brasiliensis, but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole. (AU)

FAPESP's process: 20/15847-2 - Impact of immunosenescence on in vitro response of B lymphocytes of individuals vaccinated against COVID-19: influence of smoking and chronic obstructive pulmonary disease
Grantee:Gil Benard
Support Opportunities: Regular Research Grants
FAPESP's process: 16/16369-1 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
Grantee:Maria da Gloria Sousa Stafocker
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 18/16146-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
Grantee:Giovanna Azevedo Celestrino
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 17/26208-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
Grantee:Maria da Gloria Sousa Stafocker
Support Opportunities: Scholarships in Brazil - Young Researchers