Fluoride varnishes supplemented with nano-sized sodium trimetaphosphate reduce enamel erosive wear in vitro

Author(s)

Paiva, Mayra Frasson ; Delbem, Alberto Carlos Botazzo ; Veri, Isabela Vecchiatti ; Sampaio, Caio ; Wiegand, Annette ; Pessan, Juliano Pelim

• Document type: Journal article
• Source: Journal of Dentistry; v. 138, p. 6-pg., 2023-09-28.

Abstract

Objective: To evaluate the effect of fluoride (F) varnishes with sodium trimetaphosphate (TMP) on erosive tooth wear (ETW) in vitro.Methods: Enamel blocks (n = 100) were divided into 5 experimental groups (n = 20/group): Placebo (Pla - without F/TMP); 5 % NaF (NaF); 5 % NaF + 5 % micrometric TMP (NaF+5 %MICRO); 5 % NaF + 2.5 % nano-sized TMP (NaF+2.5 %NANO), and 5 % NaF + 5 % nano-sized TMP (NaF+5 %NANO). Blocks received a single varnish application (6 h contact), and were submitted to 4 daily erosive challenges (ERO, 0.05 M citric acid, pH 3.2, 90 s, under agitation), for 5 days. After ERO, half of the blocks (n = 10/group) were subjected to brushing abrasion (ERO+ABR). Profilometry, surface hardness (SH), and cross-sectional hardness (Delta KHN) were determined. The data were submitted to 2-way ANOVA and Fisher's LSD test (p < 0.05).Results: Enamel wear was significantly lower for ERO compared with ERO+ABR for all varnishes tested (p < 0.001), following the pattern NaF+5 %NANO < NaF+5 %MICRO < NaF < NaF+2.5 %NANO < Pla (both for ERO and ERO+ABR). The highest SH loss was observed for Pla and the lowest for NaF (ERO) and NaF+2.5 %NANO (ERO+ABR), without significant differences among NaF+2.5 %NANO, NaF, and NaF+5 %MICRO. The highest Delta KHN values were observed for NaF+5 %MICRO and NaF+5 %NANO at 5-30 mu m, with less marked differences among the groups at 30-70 mu m (ERO and ERO+ABR).Conclusions: The addition of TMP to F varnishes significantly improves protection against ETW in vitro. The use of 5 % nano-sized TMP further enhances such effects. (AU)

• FAPESP's process: 19/02354-0 - Development of a fluoride varnish formulation containing nano-sized sodium trimetaphosphate: effects on enamel erosion and on erosive enamel wear using in vitro and in situ protocols
• Grantee: Juliano Pelim Pessan
• Support Opportunities: Regular Research Grants