Photodynamic therapy for nodular basal cell carcinoma up to 5mm located on high-risk area: Effectiveness and long-term follow-up results

Author(s)

Salvio, Ana Gabriela ; Requena, Michelle Barreto ; Stringasci, Mirian Denise ; Fregolenti, Bianca A. ; Medero, Maira M. C. ; Silva, Rosilene G. S. ; Bagnato, Vanderlei Salvador

• Document type: Journal article
• Source: Photodiagnosis and Photodynamic Therapy; v. 45, p. 3-pg., 2024-02-27.

Abstract

Significance: Response rates evaluation of photodynamic therapy (PDT) for nodular basal cell carcinoma (BCC) treatment located on high-risk and low-risk areas of the face. Approach: Two groups of nodular BCC were selected, debulked, and received 20% methyl aminolevulinate (MAL) hydrochloride cream. After 3 h, the first irradiation was performed (20 min, 150 J/cm2). Then, the cream was reapplied, and a second irradiation was performed after 1.5 h (20 min, 150 J/cm2). Clearance at 30 days and recurrence-free survival rate were evaluated. Results: The clearance at 30 days after PDT was 89% for the low-risk area group and 87% for the high-risk group. The recurrence-free survival at 60 months was 82% and 85% for the high-risk and low-risk groups, respectively. Conclusions: No significant differences were observed between groups nor for clearance at 30 days, nor recurrence-free follow-up. These results make PDT possible option for nodular BCC less than 5 mm located in high-risk areas. (AU)

• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 22/10860-6 - USE OF DISSOLVING MICRONEEDLES CONTAINING AMINOLEVULINIC ACID FOR PHOTODYNAMIC THERAPY
• Grantee: Michelle Barreto Requena
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Projects - Thematic Grants