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Environmental factors and their impact on chronic pain development and maintenance

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Author(s):
Sant'Anna, Morena Brazil ; Kimura, Louise Faggionato ; Vieira, Willians Fernando ; Zambelli, Vanessa Olzon ; Novaes, Leonardo Santana ; Hosch, Natalia Gabriele ; Picolo, Gisele
Total Authors: 7
Document type: Journal article
Source: PHYSICS OF LIFE REVIEWS; v. 48, p. 22-pg., 2024-02-05.
Abstract

It is more than recognized and accepted that the environment affects the physiological responses of all living things, from bacteria to superior vertebrates, constituting an important factor in the evolution of all species. Environmental influences range from natural processes such as sunlight, seasons of the year, and rest to complex processes like stress and other mood disorders, infections, and air pollution, being all of them influenced by how each creature deals with them. In this chapter, it will be discussed how some of the environmental elements affect directly or indirectly neuropathic pain, a type of chronic pain caused by a lesion or disease of the somatosensory nervous system. For that, it was considered the edge of knowledge in translational research, thus including data from human and experimental animals as well as the applicability of such findings. (AU)

FAPESP's process: 19/21158-8 - Study of photobiomodulation effects on the mitochondrial metabolism of dorsal root ganglia primary afferent neurons in a model of Peripheral Diabetic Neuropathy
Grantee:Willians Fernando Vieira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/26414-2 - Electrophysiological characterization of primary cilium ionic currents of dorsal root ganglia neurons upon inflammatory stimulation and their modulation by crotalphine
Grantee:Louise Faggionato Kimura Vieira
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 21/14831-8 - Role of the mitochondrial dynamics in the neuropathy induced by Paclitaxel
Grantee:Vanessa Olzon Zambelli
Support Opportunities: Regular Research Grants
FAPESP's process: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling
Grantee:Hugo Aguirre Armelin
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 19/05882-8 - The role of crotalphine in the primary cilium dynamics of primary afferent neurons: novel insights for the study of analgesic compounds
Grantee:Louise Faggionato Kimura Vieira
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/24631-6 - Gut-to-brain vagal afferences stimulation and its effects on the stress-induced depressive-like symptoms in mice
Grantee:Leonardo Santana Novaes
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 18/19599-3 - The role of glucocorticoids and the vagus nerve afferences on the neuronal activity and plasticity of central circuits and their implications for stress-induced anxiety in rats
Grantee:Leonardo Santana Novaes
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 23/05626-7 - ROLE OF MITOCHONDRIAL DYNAMICS IN THE DEVELOPMENT OF PACLITAXEL-INDUCED AXONAL DEGENERATION
Grantee:Natália Gabriele Hösch
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 21/10982-1 - Influence of transcranial near infrared radiation in cerebral blood flow through blood-oxygenation-level dependent (BOLD) signal in patients with major depressive disorder (MDD)
Grantee:Willians Fernando Vieira
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor