The Tiny Big Difference: Nanotechnology in Photoprotective Innovations - A Systematic Review

Author(s)

Nascimento Junior, Jose Adao Carvalho ; Santos, Anamaria Mendonca ; Oliveira, Ana Maria Santos ; Santos, Alcimary Bispo ; Araujo, Adriano Antunes de Souza ; Aragon, Diana Marcela ; Frank, Luiza Abrahao ; Serafini, Mairim Russo

• Document type: Journal article
• Source: AAPS PHARMSCITECH; v. 25, n. 7, p. 21-pg., 2024-09-07.

Abstract

UV radiation causes long- and short-term skin damage, such as erythema and skin cancer. Therefore, the use of sunscreens is extremely important. However, concerns about UV filter safety have prompted exploration into alternative solutions, with nanotechnology emerging as a promising avenue. This systematic review identified 23 experimental studies utilizing nanocarriers to encapsulate sunscreens with the aim of enhancing their efficacy and safety. Polymeric and lipid nanoparticles are frequently employed to encapsulate both organic and inorganic UV filters along with natural antioxidants. Nanocarriers have demonstrated benefits including reduced active ingredient usage, increased sun protection factor, and mitigated photoinstability. Notably, they also decreased the skin absorption of UV filters. In summary, nanocarriers represent a viable strategy for improving sunscreen formulations, offering enhanced physicochemical properties and bolstered photoprotective effects, thereby addressing concerns regarding UV filter safety and efficacy in cosmetic applications. (AU)

• FAPESP's process: 14/50928-2 - INCT 2014: Pharmaceutical Nanotechnology: a transdisciplinary approach
• Grantee: Maria Vitória Lopes Badra Bentley
• Support Opportunities: Research Projects - Thematic Grants