In vitro results with minimal blood toxicity of a combretastatin A4 analogue

Author(s):Show less -

Chagas, Camila ; Mansano, Jaqueline Vital ; da Silva, Emerson Barbosa ; Petri, Giuliana ; Reis, Beatriz da Costa Aguiar Alves ; Schumacher, Maria Lucia ; Haddad, Paula Silvia ; Pereira, Edimar Cristiano ; Britos, Tatiane Nassar ; Barreiro, Eliezer J. ; Lima, Lidia Moreira ; Ferreira, Fabio Furlan ; Fonseca, Fernando Luiz Affonso

• Document type: Journal article
• Source: INVESTIGATIONAL NEW DRUGS; v. 42, n. 3, p. 8-pg., 2024-05-17.

Abstract

Cancer is a disease caused by uncontrolled cell growth that is responsible for several deaths worldwide. Breast cancer is the most common type of cancer among women and is the leading cause of death. Chemotherapy is the most commonly used treatment for cancer; however, it often causes various side effects in patients. In this study, we evaluate the antineoplastic activity of a parent compound based on a combretastatin A4 analogue. We test the compound at 0.01 mg mL(- 1), 0.1 mg mL(- 1), 1.0 mg mL(- 1), 10.0 mg mL(- 1), 100.0 mg mL(- 1), and 1,000.0 mg mL(- 1). To assess molecular antineoplastic activity, we conduct in vitro tests to determine the viability of Ehrlich cells and the blood mononuclear fraction. We also analyze the cytotoxic behavior of the compound in the blood and blood smear. The results show that the molecule has a promising antineoplastic effect and crucial anticarcinogenic action. The toxicity of blood cells does not show statistically significant changes. (AU)

• FAPESP's process: 23/01502-1 - Synthesis, characterization, and solubility study of new crystalline forms of antineoplastic agents
• Grantee: Fabio Furlan Ferreira
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/12219-0 - Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles
• Grantee: Camila dos Santos Chagas
• Support Opportunities: Scholarships in Brazil - Doctorate