| Full text | |
| Author(s): |
Berdeville, Caio Henrique de Souza Ferreira
;
Silva-Amaral, Danyelle
;
Dalgalarrondo, Paulo
;
Banzato, Claudio E. M.
;
Martins-de-Souza, Daniel
Total Authors: 5
|
| Document type: | Journal article |
| Source: | NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS; v. 168, p. 18-pg., 2025-01-01. |
| Abstract | |
Schizophrenia is characterized by symptoms such as delusions, hallucinations, and avolition. The diagnosis is clinical, based on interviews and the main treatment involves antipsychotics. Currently, given the lack of clinically applicable biomarkers for schizophrenia, there is no molecular test based on its biological mechanisms to assist psychiatrists either in the prediction or diagnosis of the disorder, nor to measure medication efficacy. This scoping review assessed original articles in English about protein biomarkers for schizophrenia with samples that could be used in a clinical context, classifying them into diagnosis, prognosis, therapeutics, risk for psychosis, and side-effects. The search was conducted on PubMed and key findings were inserted on a summary table. We discussed the methodologies used in these papers, suggested protein panels for validation in longitudinal research, and proposed a hypothesis to explain the observed variability in results. This heterogeneity is explored in light of the debated validity of this construct, applying recent discussions and the disorder's history. Our data suggest that there is insufficient evidence to integrate protein biomarkers into clinical psychiatry for schizophrenia, not due to study quality, but possibly due to flaws in the current diagnostic system. We propose exploring alternative categorization systems. (AU) | |
| FAPESP's process: | 23/01211-7 - Cannabidiol effects on glucose metabolism and autophagy in astrocytes in the context of schizophrenia |
| Grantee: | Danyelle Silva Amaral |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 24/00735-5 - Characterizing the intracellular proteome associated with combined venlafaxine and atypical antipsychotic treatment in a human immature oligodendrocyte cell line |
| Grantee: | Caio Henrique de Souza Ferreira Berdeville |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 17/25588-1 - From the basic understanding to clinical biomarkers to schizophrenia: a neuroproteomics-centered multidisciplinary study |
| Grantee: | Daniel Martins-de-Souza |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/16373-0 - Investigating the particularities of atypical antipsychotics by assessing the oligodendrocyte secretome |
| Grantee: | Caio Henrique de Souza Ferreira Berdeville |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |