| Full text | |
| Author(s): |
Rodrigues, Karine Pereira
;
Aguilar, Bruno Augusto
;
Sanchez-Delgado, Juan Carlos
;
da Veiga, Ana Catarine
;
Velasco, Tallys Eduardo
;
Chinellato, Naiara Teixeira
;
Dilarri, Maria Eduarda
;
de Souza, Hugo Celso Dutra
Total Authors: 8
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 14, n. 1, p. 11-pg., 2024-09-13. |
| Abstract | |
Systemic arterial hypertension is accompanied by autonomic impairments that, if not contained, promotes cardiac functional and morphological damages. Pyridostigmine bromide (PYR) treatment results in positive effects on autonomic control and beneficial cardiac remodeling. These findings were also observed after aerobic physical training (APT). However, little is known about PYR effects on left ventricular contractility, mainly when it is combined with APT. We aimed to investigate the effects of chronic acetylcholinesterase inhibition on cardiac autonomic tone balance, coronary bed reactivity, and left ventricular contractility in spontaneously hypertensive rats (SHR) submitted to APT. Male SHR (18 weeks) were divided into two groups (N = 16): untrained and submitted to APT for 14 weeks (18th to 32nd week). Half of each group was treated with PYR (15 mg/kg/day) for two weeks (31st to 32nd week). The experimental protocol consisted of recording hemodynamic parameters, double autonomic blockade with atropine and propranolol, and assessment of coronary bed reactivity and ventricular contractility in isolated hearts using the Langendorff technique. PYR and APT reduced blood pressure, heart rate, and sympathetic influence on the heart. The Langendorff technique showed that APT increased coronary perfusion pressure and left ventricle contractility in response to coronary flow and beta-agonist administration. However, treatment with PYR annulled the effects of APT. In conclusion, although chronic treatment with PYR reduces cardiac sympathetic tonic influence, it does not favor coronary bed reactivity and cardiac contractility gains. PYR treatment in the trained SHR group nullified the coronary vascular reactivity and cardiac contractility gains. (AU) | |
| FAPESP's process: | 22/02553-6 - Modulation role of aerobic physical training on hemodynamic and heart morphofunctional adaptations resulting from hypertension associated with ovarian hormone deprivation |
| Grantee: | Bruno Augusto Aguilar |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 21/14938-7 - Physiopathological implications of hypertension associated with ovarian failure on cardiac morphology and function: modulating role of aerobic physical training |
| Grantee: | Hugo Celso Dutra de Souza |
| Support Opportunities: | Regular Research Grants |