In Situ Expression of TNF-α and IL-10 in Human Dermatophytosis Lesions due to Trichophyton rubrum

Author(s)

Reis, Ana Paula Carvalho ; Correia, Franciele Fernandes ; Celestrino, Giovanna Azevedo ; Pagliari, Carla ; Criado, Paulo Ricardo ; Lalwani, Pritesh Jaychand ; Benard, Gil ; Sousa, Maria Gloria Teixeira

• Document type: Journal article
• Source: Mycopathologia; v. 189, n. 6, p. 5-pg., 2024-12-01.

Abstract

Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-alpha and IL-10 in human dermatophytosis. Expression of TNF-alpha and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-alpha and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response. (AU)

• FAPESP's process: 18/16146-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
• Grantee: Giovanna Azevedo Celestrino
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/16369-1 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
• Grantee: Maria da Gloria Sousa Stafocker
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/26208-8 - Chronic disseminated dermatophytosis due to Trichophyton rubrum: role of neutrophils in the effector mechanisms and in the modulation of the adaptive response of the human infection
• Grantee: Maria da Gloria Sousa Stafocker
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 18/24175-8 - In situ immune response in human disseminated chronic dermatophytosis: participation of c type lectin receptors
• Grantee: Ana Paula Carvalho dos Reis
• Support Opportunities: Scholarships in Brazil - Scientific Initiation