Effects of Calendula officinalis extract on liver histopathology, lipid profile, and oxidative stress in rats submitted to a diet rich in cholesterol and carbohydrates

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Fontes, Gleide Gatti ; Freitas, Rodrigo de Barros ; Almeida, Palloma Porto ; Lima, Luciana Moreira ; Cardoso, Silvia Almeida ; Pizziolo, Virginia Ramos ; Tabach, Ricardo ; Wanderley, Almir Goncalves ; Arida, Ricardo Mario ; Caricati-Neto, Afonso ; Taha, Murched Omar ; de Carvalho, Camilo Amaro ; Tallo, Fernando Sabia ; Menezes-Rodrigues, Francisco Sandro

• Document type: Journal article
• Source: Acta Cirurgica Brasileira; v. 38, p. 13-pg., 2023-01-01.

Abstract

Purpose: To evaluate the modulatory properties of Calendula officinalis L. (Asteraceae) (C. officinalis) extract on cafeteria diet-fed rats. Methods: A cafeteria diet was administered ad libitum for 45 days to induce dyslipidemia. Then, the rats were treated with the formulations containing C. officinalis in the doses of 50, 100, and 150 mg/kg or only with the vehicle formulation; the control group received a commercial ration. Results: The cafeteria diet decreased glutathione S-transferase activity and high-density lipoprotein plasmatic levels and damaged the hepatic architecture. The C. officinalis extract was able to reduce lipid infiltration in liver tissue and to modulate oxidative stress and lipid profile markers. Conclusion: The correlations between the variables suggest a pathological connection between oxidative stress markers and serum lipid profile. (AU)

• FAPESP's process: 22/10696-1 - Study of morphophysiological changes in the brain of rats submitted to a physical exercise program throughout life and during aging
• Grantee: Ricardo Mario Arida
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/25565-1 - New therapeutic approach of the Parkinson´s disease: Neuroprotection stimulated by pharmacological modulation of the intracellular signaling by Ca2+/cAMP/NO
• Grantee: Afonso Caricati Neto
• Support Opportunities: Regular Research Grants