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Effects of fatty acids of vegetable oils on lipid metabolism and oxidative stress in rats fed high-fat diet rich in fructose

Grant number: 15/01348-6
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2015
Effective date (End): February 28, 2017
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Alceu Afonso Jordão Junior
Grantee:Camila Sanches Manca
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


NAFLD is related to the growing causes of morbidity and mortality of liver diseases. Its incidence is related to obesity and comorbidities related to this, which has aroused great interest in the research. The quantitative modulation of diet may promote or delay disease. Thus, therapies aimed to delay or reduce the alcoholic fatty liver could not alleviate liver damage, improve liver function and slow its progression. The objectives of this study were to assess the consumption of vegetable oils rich in MUFAs and PUFAs commercially used in the prevention or reduction of hepatic steatosis analyzing parameters of liver and lipid metabolism, oxidative stress and slowing the progression of NAFLD. The non-alcoholic steatosis is induced by high-fat diet rich in fructose. The animals will be divided into the following groups: Control + HL * (n = 10); HL Group * AZ (n = 10); HL * CN group (n = 10); Group HL * M (n = 10); HL * S group (n = 10). After 60 days of treatment with diet and their oils, the animals were euthanized by decapitation for the following analyzes: histopathology, quantification of the total liver fat and serum and hepatic fatty acids, determination of total proteins, liver enzymes, glucose and determination of stress oxidative and antioxidant activity reduced by GSH and quantification of vitamin E, and hepatic and serum retinol. (AU)

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
MANCA, Camila Sanches. Effects of different fatty acids on lipid metabolism and oxidative stress in C57/BL mice fed a high fat diet and rich in fructose. 2017. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto Ribeirão Preto.

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