Estimating an EQ-5D-Y-3L Value Set for Brazil

Author(s)

xSanto, Caique Melo Parit Raja ; Miyamoto, Gisela Cristiane ; Santos, Veronica Souza ; Ben, angela Jornada ; Finch, Aureliano Paolo ; Roudijk, Bram ; de Jesus-Moraleida, Fabianna Resende ; Stein, Airton Tetelbom ; Santos, Marisa ; Yamato, Tie Parma

• Document type: Journal article
• Source: PHARMACOECONOMICS; v. 42, n. 9, p. 17-pg., 2024-07-02.

Abstract

IntroductionThe EQ-5D-Y-3L is a generic measure of health-related quality of life in children and adolescents. Although the Brazilian-Portuguese EQ-5D-Y-3L version is available, there is no value set for it, hampering its use in economic evaluations. This study aimed to elicit a Brazilian EQ-5D-Y-3L value set based on preferences of the general adult population.MethodsTwo independent samples of adults participated in an online discrete choice experiment (DCE) survey and a composite time trade-off (cTTO) face-to-face interview. The framing was "considering your views for a 10-year-old child". DCE data were analyzed using a mixed-logit model. The 243 DCE predicted values were mapped into the observed 28 cTTO values using linear and non-linear mapping approaches with and without intercept. Mapping approaches' performance was assessed to estimate the most valid method to rescale DCE predicted values using the model fit (R2), Akaike Information Criteria (AIC), root mean squared error (RMSE), and mean absolute error (MAE).ResultsA representative sample of 1376 Brazilian adults participated (DCE, 1152; cTTO, 211). The linear mapping without intercept (R2 = 96%; AIC, - 44; RMSE, 0.0803; MAE, - 0.0479) outperformed the non-linear without intercept (R2 = 98%; AIC, - 63; RMSE, 0.1385; MAE, - 0.1320). Utilities ranged from 1 (full health) to - 0.0059 (the worst health state). Highest weights were assigned to having pain or discomfort (pain/discomfort), followed by walking about (mobility), looking after myself (self-care), doing usual activities (usual activities), and feeling worried, sad, or unhappy (anxiety/depression).ConclusionThis study elicited the Brazilian EQ-5D-Y-3L value set using a mixed-logit DCE model with a power parameter based on a linear mapping without intercept, which can be used to estimate the quality-adjusted life-years for economic evaluations of health technologies targeting the Brazilian youth population. (AU)

• FAPESP's process: 19/12049-0 - Prevalence and prognostic factors of musculoskeletal pain in children and adolescents in São Paulo City
• Grantee: Verônica Souza Santos
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 21/08776-4 - Prevalence, costs and treatment of musculoskeletal pain in children and adolescents
• Grantee: Caique de Melo do Espirito Santo
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• FAPESP's process: 17/17484-1 - Prevalence and prognostic factors of musculoskeletal pain in children and adolescents in São Paulo city
• Grantee: Tiê Parma Yamato
• Support Opportunities: Research Grants - Young Investigators Grants