In vitro diffusion of plant phenolics through the skin: A review update

Author(s)

Silva, Gislaine C. ; Rodrigues, Rodney A. F. ; Bottoli, Carla B. G.

• Document type: Journal article
• Source: International Journal of Cosmetic Science; v. 46, n. 2, p. 23-pg., 2023-12-11.

Abstract

ObjectiveExcessive skin exposure to deleterious environmental variables results in inflammation as well as molecular and cellular impairments that compromise its functionality, aesthetic qualities, and overall well-being. The implementation of topical administration of antioxidants and other compounds as a method for preventing or reversing damage is a rational approach. Numerous phenolic compounds derived from plants have demonstrated capabilities such as scavenging free radicals and promoting tissue healing. However, the primary obstacle lies in effectively delivering these compounds to the specific place on the skin, and accurately forecasting their diffusion through the skin can assist in determining the most effective tactics. Hence, this article provides a comprehensive analysis of recent literature pertaining to the in vitro skin diffusion characteristics of plant phenolics. The aim is to gain a deeper understanding of their behaviour when present in various forms such as solutions, suspensions, and formulations.MethodThe data on plant extracts and isolated plant phenolic compounds in vitro skin diffusion assays published over the last six years were compiled and discussed.ResultsEven though the gold standard Franz diffusion cell is the most commonly used in the assessment of in vitro plant phenolic skin diffusion profiles, a plethora of skin models and assay conditions are reported for a variety of compounds and extracts in different vehicles.ConclusionThe presence of numerous models and vehicles poses a challenge in creating correlations among the existing data on plant phenolic compounds. However, it is possible to draw some general conclusions regarding molecular, vehicle, and skin characteristics based on the gathered information. ObjectifUne exposition excessive de la peau a des variables environnementales deleteres entraine une inflammation ainsi que des deficiences moleculaires et cellulaires qui compromettent sa fonctionnalite, ses qualites esthetiques et son bien-etre general. La mise en oe uvre de l'administration topique d'antioxydants et d'autres composes comme methode de prevention ou d'inversion des dommages est une approche rationnelle. De nombreux composes phenoliques derives de plantes ont demontre des capacites telles que l'elimination des radicaux libres et la promotion de la cicatrisation des tissus. Cependant, le principal obstacle reside dans l'administration efficace de ces composes a un endroit specifique de la peau, et une prevision precise de leur diffusion a travers la peau peut aider a determiner les tactiques les plus efficaces. Par consequent, cet article fournit une analyse complete de la litterature recente concernant les caracteristiques de diffusion cutanee in vitro des composes phenoliques vegetaux. L'objectif est de mieux comprendre leur comportement lorsqu'ils sont presents sous diverses formes telles que solutions, suspensions et formulations.Les donnees sur les extraits de plantes et les composes phenoliques vegetaux isoles in vitro par diffusion cutanee, publiees au cours des six dernieres annees, ont ete compilees et discutees.ResultatsMeme si la cellule de diffusion Franz de reference est la plus couramment utilisee dans l'evaluation des profils de diffusion cutanee phenoliques vegetales in vitro, une plethore de modeles de peau et de conditions d'analyse sont rapportees pour une variete de composes et d'extraits dans differents vehicules.La presence de nombreux modeles et vehicules pose un defi dans la creation de correlations entre les donnees existantes sur les composes phenoliques vegetaux. Cependant, il est possible de tirer des conclusions generales concernant les caracteristiques moleculaires du vehicule et de la peau sur la base des informations recueillies. In vitro diffusion of plant phenolics.image (AU)

• FAPESP's process: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis
• Grantee: Marco Aurelio Zezzi Arruda
• Support Opportunities: Research Projects - Thematic Grants