Osteoconductive composite membranes produced by rotary jet spinning bioresorbable PLGA for bone regeneration

Author(s)

Rodrigues, Isabella Caroline Pereira ; Pereira, Karina Danielle ; Luchessi, Augusto Ducati ; Lopes, Eder Socrates Najar ; Gabriel, Lais Pellizzer

• Document type: Journal article
• Source: JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION; v. N/A, p. 14-pg., 2024-07-27.

Abstract

Bone defects and injuries are common, and better solutions are needed for improved regeneration and osseointegration. Bioresorbable membranes hold great potential in bone tissue engineering due to their high surface area and versatility. In this context, polymers such as poly(lactic-co-glycolic acid) (PLGA) can be combined with osteoconductive materials like hydroxyapatite (HA) nanoparticles (NPs) to create membranes with enhanced bioactivity and bone regeneration. Rotary Jet spinning (RJS) is a powerful technique to produce these composite membranes. This study presents an innovative and efficient method to obtain PLGA-HA(NPs) membranes with continuous fibers containing homogeneous HA(NPs) distribution. The membranes demonstrated stable thermal degradation, allowing HA(NPs) quantification. In addition, the PLGA-HA(NPs) presented osteoconductivity, were not cytotoxic, and had high cell adhesion when cultured with pre-osteoblastic cells. These findings demonstrate the potential of RJS to produce PLGA-HA(NPs) membranes for easy and effective application in bone regeneration. (AU)

• FAPESP's process: 20/07923-0 - Development of bioactive bioinks and production of bioabsorbable custom scaffolds by additive manufacturing and rotary jet spinning to bone tissue repair
• Grantee: Laís Pellizzer Gabriel
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/14679-9 - Development of pharmacological and osteoconductive scaffolds based on additive manufactured Ti6Al4V and bioresorbable rotary jet spun membranes
• Grantee: Isabella Caroline Pereira Rodrigues
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 23/11076-0 - Biofabrication and Tissue Engineering applied in the development of osteoconductive and pharmacological three-dimensional matrices to obtain bone implants
• Grantee: Laís Pellizzer Gabriel
• Support Opportunities: Regular Research Grants