Silk fibroin-derived electrospun materials for biomedical applications: A review

Author(s)

Santos, Francisco Vieira dos ; Siqueira, Renato Luiz ; Ramos, Lucas de Morais ; Yoshioka, Sergio Akinobu ; Branciforti, Marcia Cristina ; Correa, Daniel Souza

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 254, p. 34-pg., 2023-11-08.

Abstract

Electrospinning is a versatile technique for fabricating polymeric fibers with diameters ranging from micro-to nanoscale, exhibiting multiple morphologies and arrangements. By combining silk fibroin (SF) with synthetic and/or natural polymers, electrospun materials with outstanding biological, chemical, electrical, physical, mechanical, and optical properties can be achieved, fulfilling the evolving biomedical demands. This review highlights the remarkable versatility of SF-derived electrospun materials, specifically focusing on their application in tissue regeneration (including cartilage, cornea, nerves, blood vessels, bones, and skin), disease treatment (such as cancer and diabetes), and the development of controlled drug delivery systems. Additionally, we explore the potential future trends in utilizing these nanofibrous materials for creating intelligent bio-materials, incorporating biosensors and wearable sensors for monitoring human health, and also discuss the bottlenecks for its widespread use. This comprehensive overview illuminates the significant impact and exciting prospects of SF-derived electrospun materials in advancing biomedical research and applications. (AU)

• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 22/05316-5 - Development of functional polymeric biomaterials aimed at tissue regeneration and healing
• Grantee: Francisco Vieira dos Santos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 17/26194-7 - Manufacturing and characterization of nanofibers de ALGINATE/SILK fibroin incorporated with pequi oil applied in the treatment of skin wounds
• Grantee: Francisco Vieira dos Santos
• Support Opportunities: Scholarships in Brazil - Master