The impact of hypoxia-inducible factors in the pathogenesis of kidney diseases: a link through cell metabolism

Author(s)

Foresto-Neto, Orestes ; da Silva, Ana Ruth Paolinetti Alves ; Cipelli, Marcella ; Santana-Novelli, Fernanda Paula Roncon ; Camara, Niels Olsen Saraiva

• Document type: Journal article
• Source: KIDNEY RESEARCH AND CLINICAL PRACTICE; v. 42, n. 5, p. 18-pg., 2023-09-01.

Abstract

Kidneys are sensitive to disturbances in oxygen homeostasis. Hypoxia and activation of the hypoxia-inducible factor (HIF) pathway alter the expression of genes involved in the metabolism of renal and immune cells, interfering with their functioning. Whether the transcriptional activity of HIF protects the kidneys or participates in the pathogenesis of renal diseases is unclear. Several studies have indicated that HIF signaling promotes fibrosis in experimental models of kidney disease. Other reports showed a protective effect of HIF activation on kidney inflammation and injury. In addition to the direct effect of HIF on the kidneys, experimental evidence indicates that HIF-mediated metabolic shift activates inflammatory cells, supporting the HIF cascade as a link between lung or gut damage and worsening of renal disease. Although hypoxia and HIF activation are present in several scenarios of renal diseases, further investigations are needed to clarify whether interfering with the HIF pathway is beneficial in different pathological contexts. (AU)

• FAPESP's process: 22/03740-4 - Sensing podocytes: connecting extra and intracellular worlds to orchestrate renal fate
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/05264-7 - Cell metabolism, microbiota and immune system: new paradigms in renal diseases physiopathology
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 21/06748-3 - The role of gut HIF-1 signaling in kidney-gut crosstalk in kidney IRI
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Regular Research Grants
• FAPESP's process: 19/02893-9 - The hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the metabolism of tubular epithelial cells and podocytes in the development and progression of experimental kidney disease
• Grantee: Orestes Foresto Neto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/01226-1 - The metabolism of Drosophila's renal tubules in calcium oxalate crystallization
• Grantee: Orestes Foresto Neto
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor