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Sensing podocytes: connecting extra and intracellular worlds to orchestrate renal fate

Grant number: 22/03740-4
Support Opportunities:Regular Research Grants
Duration: August 01, 2022 - July 31, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Convênio/Acordo: Monash University
Principal Investigator:Niels Olsen Saraiva Câmara
Grantee:Niels Olsen Saraiva Câmara
Principal researcher abroad: John Frederick Bertram
Institution abroad: Monash University, Australia
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers: Luise McEwen ; Maria Oliveira de Souza ; Orestes Foresto Neto ; Vinicius de Andrade Oliveira
Associated research grant:21/06748-3 - The role of gut HIF-1 signaling in kidney-gut crosstalk in kidney IRI, AP.R
Associated grant(s):23/00686-1 - Interaction between proximal tubular cells and podocytes: peroxisome as interaction mediator, AP.R


Chronic kidney diseases (CKD), mainly Glomerulopathies (GPs), are major health issues worldwide. GPs are difficult to manage due to variable responses to treatment and chances of reappearance after transplantation. Podocytes are the central cell in numerous GPs and CKD, playing crucial roles in maintaining renal physiology. We hypothesize that podocytes are renal-sensing cells that connect the extracellular world with intracellular organelles and signaling pathways, determining cell function and survival in GP and CKD, ultimately influencing renal functional fate. Podocyte number and morphology and new functions addressed in this proposal dictate survival and fitness of kidneys when facing stresses and injuries. (AU)

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