New biotransformation pathways from sulfamethoxazole and ciprofloxacin removal in sewage treatment along the spatial profile of an anaerobic fixed bed bioreactor

Author(s)

Carneiro, Rodrigo B. ; Sabatini, Carolina A. ; Titato, Guilherme M. ; Ferreira, Tanare C. R. ; Zaiat, Marcelo ; Santos-Neto, Alvaro J.

• Document type: Journal article
• Source: BIORESOURCE TECHNOLOGY REPORTS; v. 17, p. 6-pg., 2022-02-01.

Abstract

In this work, the biotransformation products (BTPs) from the removal of the antibiotics sulfamethoxazole (SMX) and ciprofloxacin (CIP) were assessed for the first time in an anaerobic packed bed biofilm reactor (APBBR) treating municipal sewage. Anaerobic batch assays at high concentrations of the antibiotics (5 mg center dot L-1) were performed to identify the BTPs generated during the SMX and CIP biodegradation. From the mass transitions of the identified BTPs, they were analyzed along the spatial profile of the APBBR fed with sewage (400 ngSMX center dot L-1 and 300 ngCIP center dot L-1). Three BTPs were identified: m/z 256 and m/z 270 from SMX, and m/z 316 from CIP. The molecular structures of the BTPs revealed that SMX biotransformation occurs in the isoxazole ring and a dehydroxylation in the CIP molecule. This study showed new biotransformation pathways of SMX and CIP during anaerobic digestion, contributing to the understanding of the fate of these pharmaceutical compounds in the environment. (AU)

• FAPESP's process: 15/04427-4 - Performance evaluation of structured and packed bed reactor for removal of sulfamethoxazole and ciprofloxacin
• Grantee: Rodrigo Braz Carneiro
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/06246-7 - Biorefinery concept applied to biological wastewater treatment plants: environmental pollution control coupled with material and energy recovery
• Grantee: Marcelo Zaiat
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications
• Grantee: Fernando Mauro Lanças
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 19/22532-0 - Anaerobic biotransformation of emerging organic micropollutants in a two-phase (acidogenic-methanogenic) treatment system treating domestic wastewater
• Grantee: Rodrigo Braz Carneiro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral