Clinicopathological analysis of hybrid carcinomas of the salivary glands: A systematic review

Author(s)

Kimura, Talita de Carvalho ; de Lima-Souza, Reydson Alcides ; Lavareze, Luccas ; Abu Egal, Erika Said ; Altemani, Albina ; Mariano, Fernanda Viviane

• Document type: Journal article
• Source: JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY; v. 126, n. 5, p. 8-pg., 2024-12-17.

Abstract

Hybrid carcinomas (HC) are the association of two or more malignant neoplasms arising within the same topographical area. The present study is a systematic review of HC of the salivary glands. This study aimed to assess HC clinicopathological features and molecular profile. Observational studies, case series, and case reports were included. PubMed, Scopus, EMBASE, Lilacs, Web of Science, and gray literature were searched until June 2024. A total of 18 articles including 34 patients were included. HC of the salivary glands is presented as a painless mass affecting mainly the parotid gland of adults with a preference for male patients. Histologically, adenoid cystic carcinoma and epithelial-myoepithelial carcinoma were the most prevalent association, being surgical excision with radiotherapy the most common treatment. The most aggressive component, even when representing only a small proportion of the tumor, should guide the patient's treatment. Further molecular studies are necessary to determine if HC are distinct entities or biologically identical to the individual neoplasms. In conclusion, this systematic review may contribute to a better understanding of this rare lesion, their biological behavior, treatments employed, and the outcome of these patients. (c) 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies. (AU)

• FAPESP's process: 20/08431-4 - METABOLOMIC PROFILING ANALYSIS IN THE MALIGNANT TRANSFORMATION OF PLEOMORPHIC ADENOMA
• Grantee: Reydson Alcides de Lima Souza
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 22/11861-6 - Comparative analysis of Adenoid Cystic Carcinoma exome in xenograft model with and without entinostat and cisplatin therapy
• Grantee: Luccas Lavareze dos Reis
• Support Opportunities: Scholarships in Brazil - Doctorate