Cytotoxicity of epoxy-encapsulated Al-doped YIG nanoparticles in MG63 osteoblast cells

Author(s)

Ortega, P. P. ; Acero, G. ; Garcia, F. G. ; Longo, E. ; Simoes, A. Z.

• Document type: Journal article
• Source: Chemical Physics Letters; v. 861, p. 6-pg., 2024-12-20.

Abstract

In this study, the structural, magnetic, and cytotoxicity towards MG63 osteoblasts-like cells of epoxy/Y3Fe5O12: 1.6 wt% Al (YIG) nanoparticles were investigated. The nanoparticles crystallized in the garnet structured of YIG without secondary phases. The magnetization curve indicated the sample is superparamagnetic, with reduced residual magnetization and coercivity field (0.80 emu/g and 3.7 mT) and magnetization saturation of 24.47 emu/g, which are desirable characteristics for biomedical applications. Cytotoxic studies were performed to investigate if the nanoparticle encapsulation with DGEBA and IPD were effective in promoting cell viability, using MG63 osteoblast-like cells as a model. The results showed cell viability of >90 %, indicating that the Al-doped YIG encapsulation with DGEBA and IPD are promising methods to enhance its biocompatibility aiming in vivo applications, such as hyperthermia treatment. (AU)

• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 23/07486-8 - Surface modification of nanostructured semiconductors via irradiation with femtosecond laser and electron beam aiming gas sensor applications
• Grantee: Pedro Paulo da Silva Ortega
• Support Opportunities: Scholarships in Brazil - Post-Doctoral