Biobased composite fibrous membrane using PLA and lignin carbon dots fabricated via solution blow spinning for wound dressing application

Author(s)

Rossi, Patricia F. ; dos Santos, Danilo M. ; Marangon, Crisiane A. ; Teodoro, Kelcilene B. R. ; Costa, Camila S. ; Inada, Natalia M. ; Correa, Daniel S. ; Orefice, Rodrigo L.

• Document type: Journal article
• Source: MATERIALS TODAY COMMUNICATIONS; v. 42, p. 12-pg., 2025-01-01.

Abstract

Traditional wound dressings have limitations in terms of their antibacterial and anti-inflammatory properties, as well as their ability to maintain a moist wound environment. Addressing these shortcomings in conventional medical materials is essential for advancing wound healing in clinical applications. Additionally, biodegradable polymeric wound dressings have gained significant attention as a promising solution to reduce the environmental impact associated with the disposal of wound dressings. In this study, we developed a nanoengineered wound dressing fabricated by solution blow spinning technique by using poly(lactic acid) (PLA) fibrous mats that integrate lignin-derived carbon dots (LCDots), further enhanced with curcumin. This unique combination leverages the antimicrobial and antioxidant properties of curcumin alongside the electrical and photoluminescent features of LCDots, creating a multifunctional dressing with enhanced wound-healing capabilities. The bioactive compounds lignin carbon dots and curcumin were incorporated into the wound dressing to provide antibacterial properties against Staphylococcus aureus and Pseudomonas aeruginosa. Besides, in vitro experiments have demonstrated the superior biocompatibility of these wound dressing platforms towards neonatal human dermal fibroblast cell lines (HDFn). Furthermore, these fibrous mats did not exhibit contact and adhesion of microorganisms according to the microbial penetration test. Additionally, the composite fibrous membrane exhibited favorable hydrophilic properties and mechanical strength, making it a promising candidate for multifunctional wound dressings. Finally, it can be combined with regenerative therapies to exploit their photoluminescent and electrical properties as a stimulus for wound healing. (AU)

• FAPESP's process: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis
• Grantee: Osvaldo Novais de Oliveira Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 23/13428-0 - Conductive composite microneedles manufactured by 3D printing and applications in wearable biosensors
• Grantee: Kelcilene Bruna Teodoro Costa
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC