Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin-controlled release

Author(s)

Bernardi, Barbara ; Malafatti, Joao Otavio Donizette ; Moreira, Ailton Jose ; Nascimento, Andressa Cristina de Almeida ; Lima, Juliana Bruzaca ; Vermeersch, Lilian Aparecida Fiorini ; Paris, Elaine Cristina

• Document type: Journal article
• Source: DISCOVER NANO; v. 20, n. 1, p. 15-pg., 2025-01-14.

Abstract

Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric fibers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 +/- 8 m2 g-1), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 degrees C/4 h). Zeolites were incorporated into polymeric nanofibers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an efficient synthesis method. The fibers produced showed good mechanical resistance and the incorporation of CLX was proven by assays to inhibit the growth of Staphylococcus aureus bacteria. The controlled release of CLX in different pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 +/- 0.02 mg L-1. These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods. (AU)

• FAPESP's process: 19/23412-9 - Obtaining of ultra-thin poly (e-caprolactone) and pectin composite fibers reinforced with zeolite for controlled drug release
• Grantee: Bruna Santostaso Marinho
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 21/14992-1 - Obtainment of nanocomposite membranes consisting of PCL/PMMA/zeolite for application as a chemical sensor in the detection of polyphenol residues from the coffee industry
• Grantee: João Otávio Donizette Malafatti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/06219-3 - Developing and disseminating new technologies for environmental remediation of emerging contaminants
• Grantee: Ailton Jose Moreira
• Support Opportunities: Generation Project Research Grant
• FAPESP's process: 23/17483-6 - Obtaining Mo-modified FeWO4 for environmental remediation of emerging contaminants by solar photocatalysis.
• Grantee: Juliana Bruzaca Lima
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 23/03632-0 - Development of sensor arrays based on zeolite nanostructures functionalized with porphyrins for polyphenol detection
• Grantee: João Otávio Donizette Malafatti
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor