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SYNTHESIS OF COAGULANTS HEMOSTATIC AGENTS BASED IN NEW ZEOLITIC MATERIALS

Grant number: 13/16754-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2013
Effective date (End): July 31, 2017
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Jose Geraldo Nery
Grantee:Juliana Bergamasco Laurenti
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

Despite the advances in medical intervention, traumatic fatal hemorrhage remains a major cause of death worldwide. Consequently, the development of effective methods for the treatment of uncontrolled hemorrhages has become a priority for in various medical research centers. In this direction, many efforts have been dedicated to the research and development of new hemostatic agents that can act more effectively to control hemorrhages. At first an ideal hemostatic agent must have the capacity to stop the bleeding both arterial and venous, be ready for use, easy to apply, durable and lightweight, stable and functional, safe and cheap. Although the majority of hemostatic agents is of an organic nature recently studies involving the use of zeolites as hemostatic agents have shown encouraging results for the control of bleeding. These studies shows that when in contact with the blood, zeolites adsorbs rapidly the water molecules in their pores, thereby concentrating the proteins and cellular elements to clot formation. Moreover, the surface of the zeolite containing negative charge provides a chemical environment favorable which acts as an activator of the contact pattern of the intrinsic coagulation cascade. The potential of zeolite as hemostatic agent has only begun to be explored effectively release of QuikClot hemostatic agent in 1990 by the American company Z-Medica Inc. In the specific case of this hemostatic agent its molecular structure or topology was the zeolite faujasite (FAU) in its form dehydrated. From this moment, the systematic study of inorganic oxides and new zeolitic materials specially modulated to be used as hemostatic agents has become a very attractive and challenging research area and, due to its great potential for technological innovation. In this context, the objectives of this research project are the synthesis, characterization and modulation of different zeolitic materials in both micrometric and nanometric scales, so that they can be used as hemostatic agents to control bleeding by accelerating the clotting process.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAURENTI, JULIANA BERGAMASCO; ZAZERI, GABRIEL; RIBEIRO POVINELLI, ANA PAULA; DE GODOY, MOACIR FERNANDES; BRAILE, DOMINGO MARCOLINO; FLORES DA ROCHA, TANIA R.; D' AMICO, ELBIO ANTONIO; NERY, JOSE GERALDO. Enhanced pro-coagulant hemostatic agents based on nanometric zeolites. Microporous and Mesoporous Materials, v. 239, p. 263-271, . (13/16754-4, 12/24259-0)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LAURENTI, Juliana Bergamasco. Synthesis of coagulant and antimicrobial hemostatic agents based on zeolite materials. 2017. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências Letras e Ciências Exatas. São José do Rio Preto São José do Rio Preto.

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Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE NANOZEÓLITAS COM ATIVIDADE HEMOSTÁTICA E PRODUTO OBTIDO BR1020160037590 - Universidade Estadual Paulista (UNESP) . José Geraldo Nery ; Juliana Bergamasco Laurenti ; Gabriel Zazeri - February 2016, 22