Development and thromboelastography characterization of hemostatic sponges based on natural polymers for surgical use

• Grant number: 17/16010-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): December 01, 2017
• Effective date (End): November 30, 2018
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Jose Geraldo Nery
• Grantee: Rodrigo Pereira Amarante
• Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil

Abstract

Despite advances in medical intervention, fatal traumatic hemorrhage remains one of the leading causes of death in the world. Thus, the development of effective methods for the treatment of uncontrolled bleeding has become a priority in several medical research centers. In this sense, many efforts have been devoted to the research and development of new hemostatic agents that can act more effectively in the control of hemorrhages. At first, an ideal hemostatic agent should have the ability to stop bleeding both arterial and venous, be available for immediate use, be easy to apply, light and durable, stable and functional, safe and inexpensive. Our research group has been working and directing part of their research in the search for new hemostatic agents. Our most recent results involve the use of zeolites as hemostatic agents for the control of bleeding. These studies have shown that when in contact with blood, zeolites readily adsorb water molecules, thereby concentrating the proteins and cellular elements essential for clot formation. Because of these promising results achieved with zeolite materials, systematic studies of specially modulated inorganic oxides to be used as hemostatic agents have become a very attractive and challenging research area due to their great potential for technological innovation. Although research on inorganic materials is well advanced, part of its results have already been deposited in the form of patents and scientific articles from international journals, the potential of using biomass-derived raw materials for syntheses of efficient hemostatic agents Was not fully explored. In this context, the search for new hemostatic materials, the objectives of this research project of scientific initiation are the syntheses, physicochemical characterization and thromboelastography studies of hemostatic sponges derived from natural polymers, in this case chitosan, for surgical use, aiming at the control Of bleeding during surgical procedures by accelerating the coagulation process. (AU)