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Synthesis of hemostatic agents from organic and inorganic biomass: modulation of the anti-hemorrhagic and anti-inflammatory action with inorganic nanoparticles, in vitro and in vivo studies aiming at surgical-hospital applications

Abstract

Despite advances in medical intervention, one of the leading causes of death worldwide is bleeding due to trauma. As a result, the development of effective hemostatic agents for hemorrhage containment has become a priority in several medical research centers. There is a plethora of topical hemostatic agents available on the market with the most diverse pharmaceutical formulations and prepared from different organic or inorganic materials, modulated according to their physicochemical properties. However, despite all this diversity of hemostatic agents, the need for new and efficient hemostatic agents is still a recurring need in surgical centers and emergency situations. Previous research carried out in our research group with the support of FAPESP resulted in the preparation, characterization and thromboelastographic studies of new hemostatic agents based on zeolitic materials (process: 2013/16754-4) and pectin (process: 2019/01858-5). The objective of this doctoral research project is to advance and deepen the study of these hemostatic materials, aiming at the modulation of these materials with the incorporation of metallic nanoparticles and oxides of Silver (Ag), Bismuth (Bi), Cerium (Ce), Copper (Cu) and Zinc (Zn), and the study of the synergistic effect between the antimicrobial and hemostatic action of these pectin-based hemostatic agents. Aiming at the potential use of new biomasses for the production of hemostatic agents, eggshells, calcium-rich inorganic biomass, will be used in the synthesis of new calcium-rich zeolites. Preliminary results obtained to date indicate that calcium-rich zeolites, such as Yugawaralite (YUG), can be synthesized from eggshells, and preliminary results from thromboelastographic studies indicate the potential of these zeolitic materials to be applied as hemostatic agents. The project will be carried out in collaboration with the Faculty of Medicine of Rio Preto (FAMERP), where studies of the antimicrobial action of the synthesized materials and their interaction with biofilms formed by bacteria (Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, Enterococcus faecalis and Peptostreptococcus spp) will be performed. In vivo studies with hemostatic agents will be carried out in collaboration with Instituto Butantã-SP and, at the international level, we intend to carry out studies of new hemostatic agents in collaboration with researchers from BAM-Federal Institute for Materials Research and Testing, Berlin) and University of Texas-Health Science Center (UTHealth)- Houston. (AU)

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