| Full text | |
| Author(s): Show less - |
Romao, Wanderson
[1]
;
Lalli, Priscila M.
[1]
;
Franco, Marcos F.
[1]
;
Sanvido, Gustavo
[1]
;
Schwab, Nicolas V.
[2]
;
Lanaro, Rafael
[3]
;
Costa, Jose Luiz
[3]
;
Sabino, Bruno D.
[4]
;
Bueno, Maria Izabel M. S.
[2]
;
de Sa, Gilberto F.
[5, 6]
;
Daroda, Romeu J.
[6]
;
de Souza, Vanderlea
[6]
;
Eberlin, Marcos N.
[1]
Total Authors: 13
|
| Affiliation: | [1] Univ Campinas UNICAMP, ThoMSon Mass Spectrometry Lab, BR-13084971 Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Inst Chem, Xray Spect Grp, BR-13084971 Campinas, SP - Brazil
[3] Univ Campinas UNICAMP, Fac Med Sci, Poison Control Ctr, BR-13084971 Campinas, SP - Brazil
[4] Carlos Eboli Inst Criminalist, BR-20060050 Rio De Janeiro - Brazil
[5] Univ Fed Pernambuco, Dept Fundamental Chem, BR-50740540 Recife, PE - Brazil
[6] Natl Inst Metrol, Directorate Ind & Sci Metrol, Div Chem Metrol, BR-25250020 Duque De Caxias, RJ - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | ANALYTICAL AND BIOANALYTICAL CHEMISTRY; v. 400, n. 9, p. 3053-3064, JUL 2011. |
| Web of Science Citations: | 34 |
| Abstract | |
Meta-chlorophenylpiperazine (m-CPP) is a new illicit drug that has been sold as ecstasy tablets. Easy ambient sonic-spray ionization mass spectrometry (EASI-MS) and X-ray fluorescence spectrometry (XRF) are shown to provide relatively simple and selective screening tools to distinguish m-CPP tablets from tablets containing amphetamines (mainly 3,4-methylenedioxymethamphetamine (MDMA)). EASI-MS detects the active ingredients in their protonated forms: {[}m-CPP + H](+) of m/z 197, {[}MDMA + H](+) of m/z 194, and {[}2MDMA + HCl + H](+) of m/z 423 and other ions from excipients directly on the tablet surface, providing distinct chemical fingerprints. XRF identifies Cl, K, Ca, Fe, and Cu as inorganic ingredients present in the m-CPP tablets. In contrast, higher Cl concentrations and a more diverse set of elements (P, Cl, Ca, Fe, Cu, Zn, Pt, V, Hf, Ti, Pt, and Zr) were found in MDMA tablets. Principal component analysis applied to XRF data arranged samples in three groups: m-CPP tablets (four samples), MDMA tablets (twenty three samples), and tablets with no active ingredients (three samples). The EASI-MS and XRF techniques were also evaluated to quantify m-CPP in ecstasy tablets, with concentrations ranging from 4 to 40 mg of m-CPP per tablets. The m-CPP could only be differentiated from its isomers (o-CPP and for the three isomers p-CPP) by traveling wave ion mobility mass spectrometry and NMR measurements. (AU) | |
| FAPESP's process: | 09/07168-9 - New applications of mass spectrometry in Forensic Chemistry |
| Grantee: | Wanderson Romão |
| Support Opportunities: | Scholarships in Brazil - Doctorate |