Coordination Compounds as Antivirals against Neglected Tropical Diseases

Author(s)

Rezende, Wallace S. ; Neto, Antonio Marcal ; Corbi, Juliano J. ; Corbi, Pedro P. ; de Paiva, Raphael E. F. ; Bergamini, Fernando R. G.

• Document type: Journal article
• Source: CHEMMEDCHEM; v. N/A, p. 18-pg., 2024-12-09.

Abstract

Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen-related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate-to-cold environments. The slow-paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation. Coordination compounds are a class of molecules that have been extensively explored as antiviral drugs for viruses such as poliovirus, HIV and, more recently, SARS-CoV-2, figuring as potential molecules to be explored and capitalized as antivirals against neglected viral strains. In this review the current efforts from the inorganic medicinal chemistry to address viral neglected tropical diseases, with emphasis to coordination compounds, is presented. Since many of neglected viruses are also arthropod-borne viruses, relying on a vector for transmission, coordination entities able to mitigate vectors are also presented as a parallel strategy to prevent and control such diseases. (AU)

• FAPESP's process: 21/10265-8 - Cancer Theranostics Innovation Center (CancerThera)
• Grantee: Carmino Antonio de Souza
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 20/09912-6 - Ativa-ETE: evaluation of innovative technologies for the removal of nitrogen and micropollutants in wastewater treatment plants (WWTP)
• Grantee: José Alberto Domingues Rodrigues
• Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE