Dihydroisocoumarins produced by Xylaria sp and Penicillium sp., endophytic fungi associated with Piper aduncum and Alibertia macrophylla

Author(s)

Oliveira, Camila M. ^[1] ; Regasini, Luis O. ^[1] ; Silva, Geraldo H. ^[2] ; Pfenning, Ludwig H. ^[3] ; Young, Maria C. M. ^[4] ; Berlinck, Roberto G. S. ; Bolzani, Vanderlan S. ^[1] ; Araujo, Angela R. ^[1]

Affiliation

^[1] Univ Estadual Paulista, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Inst Quim, BR-14800900 Araraquara, SP - Brazil

^[2] Univ Fed Sergipe, Dept Quim, BR-49500000 Itabaiana, SE - Brazil

^[3] Univ Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG - Brazil

^[4] Inst Bot, Seccao Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo - Brazil

• Document type: Journal article
• Source: PHYTOCHEMISTRY LETTERS; v. 4, n. 2, p. 93-96, JUN 15 2011.
• Web of Science Citations: 27

Abstract

The dihydroisocoumarin (3R, 4R)-3,4-dihydro-4,6-dihydroxy-3-methyl-1-oxo-1H-isochromene-5-carboxylic acid (1) was isolated from Xylaria sp., a fungus associated with Piper aduncum (Piperaceae). Additionally, two known compounds, (R)-7-hydroxymellein (2) and (3R, 4R)-4,7-dihydroxymellein (3), were isolated from Penicillium sp. associated to Alibertia macrophylla (Rubiaceae). The structures of all compounds were elucidated by analysis of spectroscopic data. The dihydrocoumarin derivatives 1-3 showed antifungal and acetylcholinesterase (AChE) inhibitory activities in vitro. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants