Magnetic seizure therapy for unipolar and bipolar depression: An up to date systematic review

Author(s)

Cavenaghi, Vitor Breseghello ; Carneiro, Adriana M. ; Cretaz, Eric ; Cabral, Bianca ; Cardoso, Caroline Benigno ; Brunoni, Andre Russowsky

• Document type: Journal article
• Source: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY; v. 26, n. 1, p. 11-pg., 2024-12-18.

Abstract

BackgroundMagnetic seizure therapy (MST) has emerged as a promising alternative to electroconvulsive therapy (ECT) for treatment-resistant depression. Previous systematic reviews and meta analysis already showed its primary results, however, there are no recent reviews updating these findings.ObjectivesThis systematic review aimed to make an updated systematic review of MST on unipolar and bipolar depression.MethodsWe conducted a search considering databases (PubMed/MEDLINE, EMBASE, Web of Science, Scopus). Studies were included if they investigated MST in human subjects for unipolar or bipolar depression, and not restricting to year or language.ResultsData resulted in 15 studies, corresponding to 300 participants that received MST. Most studies were pilot, open-label or secondary analyses (n = 12). Participants that received MST had a response and remission rates ranging from 26.9% to 72.2% and 11.1% to 61.1%, respectively. The most common stimulation regions were vertex and prefrontal cortex, with frequencies between 25-100 Hz and duration of 6-24 sessions (2-3 times a week). Few side effects were reported.ConclusionsMST shows to be effective and well-tolerated treatment for depression. Larger, double-blinded RCTs with standardised mood, cognitive, and side effect assessments are needed to confirm these findings. (AU)

• FAPESP's process: 19/06009-6 - Non-implantable neuromodulation therapies: a perspective for the depressed brain
• Grantee: Geraldo Busatto Filho
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 24/06902-0 - Hot and cold cognition in patients with depressive episode during magnetic and electro convulsive therapies: data from a randomized clinical study
• Grantee: Adriana Carneiro
• Support Opportunities: Scholarships in Brazil - Post-Doctoral