Mitochondrial redox state, bioenergetics, and calcium transport in caloric restriction: A metabolic nexus

Author(s)

Vilas-Boas, Eloisa A. ; Kowaltowski, Alicia J.

• Document type: Journal article
• Source: Free Radical Biology and Medicine; v. 219, p. 20-pg., 2024-04-29.

Abstract

Mitochondria congregate central reactions in energy metabolism, many of which involve electron transfer. As such, they are expected to both respond to changes in nutrient supply and demand and also provide signals that integrate energy metabolism intracellularly. In this review, we discuss how mitochondrial bioenergetics and reactive oxygen species production is impacted by dietary interventions that change nutrient availability and impact on aging, such as calorie restriction. We also discuss how dietary interventions alter mitochondrial Ca2+ 2 + transport, regulating both mitochondrial and cytosolic processes modulated by this ion. Overall, a plethora of literature data support the idea that mitochondrial oxidants and calcium transport act as integrating signals coordinating the response to changes in nutritional supply and demand in cells, tissues, and animals. (AU)

• FAPESP's process: 20/06970-5 - Mitochondrial ion transporters as sensors and regulators in energy metabolism
• Grantee: Alicia Juliana Kowaltowski
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
• Grantee: Ohara Augusto
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 21/02481-2 - Energy metabolism regulation by mitochondrial Ca2+ transport in the liver
• Grantee: Eloisa Aparecida Vilas Boas
• Support Opportunities: Scholarships in Brazil - Post-Doctoral