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Effects of caloric restriction on mitochondrial Ca2+ transport in cardiac and skeletal muscles

Grant number: 19/05226-3
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): May 01, 2019
Effective date (End): May 31, 2022
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Alicia Juliana Kowaltowski
Grantee:Julian David Cualcialpud Serna
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

We recently found that obese, ad libitum fed, rats and mice present lower mitochondrial Ca2+ uptake capacity in both the brain and liver when compared to lean, calorically-restricted animals. This was the first evidence that a dietary intervention can change mitochondrial Ca2+ transport properties. Ca2+ is a central metabolic regulator and, thus, diet-induced changes in mitochondrial Ca2+ transport may be both physiologically and pathologically relevant in other organs. This proposal aims to uncover possible changes in mitochondrial Ca2+ uptake in heart and skeletal muscle, and study physiological and pathological consequences of possible changes. (AU)