Effects of caloric restriction on mitochondrial Ca2+ transport in cardiac and skeletal muscles

• Grant number: 19/05226-3
• Support type: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): May 01, 2019
• Effective date (End): May 31, 2023
• Field of knowledge: Biological Sciences - Biochemistry - Metabolism and Bioenergetics
• Principal researcher: Alicia Juliana Kowaltowski
• Grantee: Julian David Cualcialpud Serna
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID

Abstract

We recently found that obese, ad libitum fed, rats and mice present lower mitochondrial Ca2+ uptake capacity in both the brain and liver when compared to lean, calorically-restricted animals. This was the first evidence that a dietary intervention can change mitochondrial Ca2+ transport properties. Ca2+ is a central metabolic regulator and, thus, diet-induced changes in mitochondrial Ca2+ transport may be both physiologically and pathologically relevant in other organs. This proposal aims to uncover possible changes in mitochondrial Ca2+ uptake in heart and skeletal muscle, and study physiological and pathological consequences of possible changes. (AU)