Effects of caloric restriction on mitochondrial morphology, dynamics, bioenergetic...
| Grant number: | 19/05226-3 |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| Effective date (Start): | May 01, 2019 |
| Effective date (End): | May 31, 2022 |
| Field of knowledge: | Biological Sciences - Biochemistry |
| Principal Investigator: | Alicia Juliana Kowaltowski |
| Grantee: | Julian David Cualcialpud Serna |
| Home Institution: | Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 13/07937-8 - Redoxome - Redox Processes in Biomedicine, AP.CEPID |
Abstract We recently found that obese, ad libitum fed, rats and mice present lower mitochondrial Ca2+ uptake capacity in both the brain and liver when compared to lean, calorically-restricted animals. This was the first evidence that a dietary intervention can change mitochondrial Ca2+ transport properties. Ca2+ is a central metabolic regulator and, thus, diet-induced changes in mitochondrial Ca2+ transport may be both physiologically and pathologically relevant in other organs. This proposal aims to uncover possible changes in mitochondrial Ca2+ uptake in heart and skeletal muscle, and study physiological and pathological consequences of possible changes. (AU) | |