| Full text | |
| Author(s): |
Beatriz Cristina Biz, Tonin
;
Carolina de Sousa, Castro-Silva
;
Frank John, Slack
;
Miriam Galvonas, Jasiulionis
Total Authors: 4
|
| Document type: | Journal article |
| Source: | RNA BIOLOGY; v. 21, n. 1, p. 13-pg., 2024-12-31. |
| Abstract | |
Long non-coding RNAs (lncRNAs) have received growing attention due to their diverse regulatory roles in cancer, including in melanoma, an aggressive type of skin cancer. The plasticity and phenotypic adaptability of melanoma cells are crucial factors contributing to therapeutic resistance. The identification of molecules playing key roles in melanoma cell plasticity could unravel novel and more effective therapeutic targets. This review presents current concepts of melanoma cell plasticity, illustrating its fluidity and dismissing the outdated notion of epithelial-mesenchymal-like transition as a simplistic binary process. Emphasis is placed on the pivotal role of lncRNAs in orchestrating cell plasticity, employing various mechanisms recently elucidated and unveiling their potential as promising targets for novel therapeutic strategies. Insights into the molecular mechanisms coordinated by lncRNAs in melanoma pave the way for the development of RNA-based therapies, holding great promise for enhancing treatment outcomes and offering a glimpse into a more effective approach to melanoma treatment. (AU) | |
| FAPESP's process: | 21/06214-9 - Analysis of the role of lncRNAs with prognostic value in Melanoma progression |
| Grantee: | Beatriz Cristina Biz Tonin |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 22/00322-7 - Identification and characterization of ncRNAs playing a role in Melanoma phenotypic plasticity |
| Grantee: | Miriam Galvonas Jasiulionis |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/20775-0 - Non-coding RNAs involved with melanoma genesis and progression |
| Grantee: | Miriam Galvonas Jasiulionis |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 21/06985-5 - Search for novel therapeutic strategies by inhibiting histone modification enzymes targeting malignant traits of melanoma cells with different phenotypes |
| Grantee: | Carolina de Sousa Castro Silva |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |