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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In Vivo Anti-Inflammatory Activity of D-Limonene in a Rat Model of Monocrotaline-Induced Pulmonary Hypertension: Implications to the Heart Function

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Author(s):
Jorge Lucas Teixeira-Fonseca [1] ; Diego Jose Belato y Orts [2] ; Polyana Leal da Silva [3] ; Michael Ramon de Lima Conceição [4] ; Hernan Hermes ; Carlos R. Prudencio ; Danilo Roman-Campos [7]
Total Authors: 7
Affiliation:
[1] Universidade Federal de São Paulo - Brasil
[2] Universidade Federal de São Paulo - Brasil
[3] Universidade Federal de São Paulo - Brasil
[4] Universidade Federal de São Paulo - Brasil
[7] Universidade Federal de São Paulo - Brasil
Total Affiliations: 7
Document type: Journal article
Source: Arquivos Brasileiros de Cardiologia; v. 121, n. 12 2024-12-13.
Abstract

Abstract Background D-limonene (D-L) is the major monocyclic monoterpene in citrus plants with anti-inflammatory properties. Pulmonary hypertension (PH) can cause right heart dysfunction and increases the risk of death, partially due to inflammatory response in the heart. Objective To evaluate the possible protective effect of D-L on cardiac function in a rat model of monocrotaline-induced PH (MCT-PH). Methods Electrocardiogram was monitored in vivo. Masson Trichrome technique was deployed to verify fibrosis in the heart. Contractility function of isolated atrial tissue was studied using organ bath chamber. Real-time quantitative PCR was applied to quantify inflammation in the right ventricle. Results The MCT-PH group showed electrical and structural heart remodeling, with the presence of fibrosis in the cardiac tissue and in vivo electrocardiographic changes. Treatment with D-L partially prevented the development of tissue fibrosis and the increase in P wave duration in the MCT-PH group. The contraction and relaxation velocity of isolated right and left atrium were accelerated in CTR and MCT-PH animals treated with D-L. Finally, D-L was able to prevent the abnormal expression of the key inflammatory cytokines (interleukin 1-β, interleukin 6 and tumor necrosis factor-α) in the right ventricle of MCT-PH animals. D-L was able to enhance the production of the anti-inflammatory cytokine Interleukin-10. Conclusion Our results showed that in vivo administration of D-L partially prevented the molecular, structural and functional remodeling of the heart in the MCT-PH model with attenuation of the inflammatory response in the heart. (AU)

FAPESP's process: 22/07256-0 - Role of SCN5A polymorphisms on pharmacological properties of pesticides against Nav1.5
Grantee:Diego Jose Orts y Belato
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 22/14133-1 - Molecular mechanisms of increased susceptibility to cardiac arrhythmias due to chronic in vivo exposure to low doses of triazole pesticides: implications for worsening heart disease caused by Pulmonary Hypertension
Grantee:Jorge Lucas Teixeira da Fonseca
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 20/14635-1 - Modeling of monogenic diseases for physiopathological studies and pharmacological tests using specialized cells derived from iPSCs
Grantee:João Bosco Pesquero
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 21/05584-7 - Assessment of acute and chronic toxicity of the heart and brain exposed to pesticides found in potable water in Brazil
Grantee:Danilo Roman Campos
Support Opportunities: Research Grants - Young Investigators Grants - Phase 2