Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Value of Ultrasound and Cytological Classification System to Predict the Malignancy of Thyroid Nodules with Indeterminate Cytology

Full text
Author(s):
Ribeiro Maia, Frederico Fernandes [1] ; Matos, Patricia S. [2] ; Pavin, Elizabeth J. [1] ; Vassallo, Jose [2] ; Zantut-Wittmann, Denise E. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Div Endocrinol, Dept Internal Med, Fac Med Sci, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Dept Pathol, Sch Med Sci, BR-13083887 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ENDOCRINE PATHOLOGY; v. 22, n. 2, p. 66-73, JUN 2011.
Web of Science Citations: 19
Abstract

Although fine-needle aspiration cytology is considered the gold standard for evaluating thyroid nodules, in about 10-30% of the cases, cytology is indeterminate. This study aimed to determine the value of cytological classification system and ultrasound (US) to predict malignancy in indeterminate thyroid nodule. This retrospective analysis enrolled 80 patients surgically treated at a single center, 75% (60) with benign vs. 25% (20) with malignant lesions at final histology. The clinical, scintigraphic, sonographic, and cytological classification (Bethesda) variables were analyzed in these selected cases of indeterminate cytology, and a prediction model was designed after the multivariate analysis. There was a 25% prevalence of malignancy (20/80). There were no differences in gender, serum thyroid-stimulating hormone and FT4 levels, thyroid auto-antibodies, thyroid dysfunction, and scintigraphic results between benign and malignant nodule groups. The border irregularity in sonographic study was at increased risk for malignancy. The cytological analysis based on Bethesda System (category IV) was an independent predictor for malignancy in indeterminate thyroid nodules. After the multivariate analysis, the model obtained showed border irregularity and Bethesda System category IV as predictive factors of malignancy in indeterminate thyroid nodules, featuring 76.9% of accuracy. This study confirmed a significant increase of risk for malignancy in thyroid nodules with indeterminate cytology showing Bethesda System category IV and suspicious features at US. These findings enhance our current limited predictive armamentarium and can be used to guide surgical decision making. (AU)

FAPESP's process: 08/10183-7 - Markers of cell proliferation, apoptosis and angiogenesis in thyroid nodule: correlation between clinical, ultrasonography, thyroid scan and cito-pathology parameters
Grantee:Denise Engelbrecht Zantut Wittmann
Support Opportunities: Regular Research Grants