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Determination of the Attenuation Coefficient by OCT in Cutaneous Melanoma After the Application of Optical Clearing Agents

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Author(s):
Martinelli, Leticia Palombo ; Moriyama, Lilian Tan ; Kurachi, Cristina
Total Authors: 3
Document type: Journal article
Source: 2024 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC 2024; v. N/A, p. 3-pg., 2024-01-01.
Abstract

Melanoma is the most aggressive skin cancer, originating from melanin-producing melanocytes, it is highly metastatic and challenging to treat. Light-based therapies such as photodynamic and photothermal treatments are promising but limited by melanin's light-absorbing properties. Optical clearing agents (OCAs), which promotes refractive index matching, can enhance these therapies by improving light penetration. In the present study, we analyzed the effect of OCAs in a cutaneous melanoma model by obtaining the attenuation coefficient using optical coherence tomography. A reduction of up to 43% in the attenuation coefficient was observed in melanoma after OCA application, confirming their effectiveness in decreasing light attenuation, allowing deeper light penetration into the tumor. (AU)

FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
Grantee:Vanderlei Salvador Bagnato
Support Opportunities: Research Projects - Thematic Grants