Determination of the Attenuation Coefficient by OCT in Cutaneous Melanoma After the Application of Optical Clearing Agents

Author(s)

Martinelli, Leticia Palombo ; Moriyama, Lilian Tan ; Kurachi, Cristina

• Document type: Journal article
• Source: 2024 SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, SBFOTON IOPC 2024; v. N/A, p. 3-pg., 2024-01-01.

Abstract

Melanoma is the most aggressive skin cancer, originating from melanin-producing melanocytes, it is highly metastatic and challenging to treat. Light-based therapies such as photodynamic and photothermal treatments are promising but limited by melanin's light-absorbing properties. Optical clearing agents (OCAs), which promotes refractive index matching, can enhance these therapies by improving light penetration. In the present study, we analyzed the effect of OCAs in a cutaneous melanoma model by obtaining the attenuation coefficient using optical coherence tomography. A reduction of up to 43% in the attenuation coefficient was observed in melanoma after OCA application, confirming their effectiveness in decreasing light attenuation, allowing deeper light penetration into the tumor. (AU)

• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 14/50857-8 - National Institute in Basic Optics and Applied to Life Sciences
• Grantee: Vanderlei Salvador Bagnato
• Support Opportunities: Research Projects - Thematic Grants