| Full text | |
| Author(s): |
Trajano, Isis P.
;
Costa, Luis Henrique Angenendt
;
Passaglia, Patricia
;
Santos, Wanderson S.
;
dos Santos, Jonathas Rodrigo
;
Alberici, Luciane Carla
;
Branco, Luiz G. S.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | CYTOKINE; v. 189, p. 7-pg., 2025-03-08. |
| Abstract | |
An abnormally elevated mortality rate is evident in cases of sepsis. To study specific mechanisms of sepsis experimentally, lipopolysaccharide (LPS) systemically administered has been used as a model, in which an exaggerated immune response, neurochemistry settings, and fever following hypothermia take place. Notably, systemic inflammation (SI) can modulate the central serotonergic pathways and being influenced by it. This influence extends to the hypothalamus, which holds a hierarchical significance in the control of body temperature (Tb). This study investigates the potential impact of orally administered fluoxetine (FLX), a selective serotonin reuptake inhibitor (SSRI) given orally for 7 days before on LPS-induced SI (1.5 mg/kg, i.v.) in rats. The assessment involved monitoring Tb, heat loss index (HLI), along non-shivering thermogenesis assessed by oxygen consumption. Cytokine levels in the spleen and blood, along with nitric oxide (NO), and prostaglandins (PGs) E2 and D2, levels were also measured. The findings reveal increased plasma NO, cytokines in plasma and spleen, and hypothalamus PGE2 levels during SI. Interestingly, FLX mitigated LPS-induced hypothermia, accompanied by a reduction in plasma and splenic NO, interleukins (IL) 6, and 10. Additionally, the results align with the hypothesis that hypothermia, blunted by FLX, develops in fact in a regulated form, as an adaptive strategy. (AU) | |
| FAPESP's process: | 22/01783-8 - Effects of fluoxetine pretreatment on endotoxemia-induced hypothermia |
| Grantee: | Isis Paiva Trajano |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 22/12290-2 - Effect of Citral on Periodontal Disease in rats |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/17681-9 - Pathophysiological changes during systemic inflammation |
| Grantee: | Luiz Guilherme de Siqueira Branco |
| Support Opportunities: | Research Projects - Thematic Grants |