| Full text | |
| Author(s): Show less - |
Fatori, Daniel
;
Shephard, Elizabeth
;
Benette, Danilo
;
Naspolini, Nathalia Ferrazzo
;
Guzman, Grover Castro
;
Wang, Jaqueline Yu Ting
;
Totolo, Pedro
;
Mafra, Anthonieta Looman
;
Isaias, Caio
;
dos Santos, Davi Pereira
;
Russo, Fabiele Baldino
;
Kobayashi, Gerson
;
Argeu, Adriana
;
Teixeira, Monike
;
Mattiello-Sverzut, Ana Claudia
;
Fernandes, Maria Teresa Bechere
;
Petian-Alonso, Danila Cristina
;
Brentani, Helena
;
Scliar, Marilia
;
Schuroff, Paulo Alfonso
;
Zuccolo, Pedro
;
Lerner, Rogerio
;
Geraldini, Stephania
;
Euclydes, Veronica Luiza Vale
;
Matijasevich, Alicia
;
de Campos, Alline Cristina
;
de Carvalho, Andre Carlos Ponce
;
Fujita, Andre
;
Taddei, Carla R.
;
Passos-Bueno, Maria Rita
;
Beltrao-Braga, Patricia
;
Polanczyk, Guilherme Vanoni
Total Authors: 32
|
| Document type: | Journal article |
| Source: | DEVELOPMENT AND PSYCHOPATHOLOGY; v. N/A, p. 11-pg., 2025-03-05. |
| Abstract | |
This paper reports the methods and preliminary findings of Germina, an ongoing cohort study to identify biomarkers and trajectories of executive functions and language development in the first 3 years of life. 557 mother-infant dyads (mean age of mothers 33.7 years, 65.2% white, 48.7% male infants) have undergone baseline and are currently collecting data for other timepoints. A linear regression was used to predict baseline Bayley-III using scores derived from data-driven sparse partial least squares utilizing a multiple holdout framework of 15 domains. Significant associations were found between socioeconomic/demographic characteristics (B = 0.29), epigenetics (B = 0.11), EEG theta (B = 0.14) and beta activity (B = 0.11), and microbiome functional pathways (B = 0.08) domains, and infant development measured by the Bayley-III at T1, suggesting potential interventions to prevent impairments. (AU) | |
| FAPESP's process: | 20/05964-1 - Effects of biological and environmental factors and psychosocial intervention on early neurodevelopmental pathways in vulnerable children |
| Grantee: | Elizabeth Shephard |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 23/04619-7 - Endocannabidiome as a tool to determine biomarkers candidates of the gut-brain-axis development during the first 1,000 days of life |
| Grantee: | Alline Cristina de Campos |
| Support Opportunities: | Regular Research Grants |