Xylarenones C-E from an Endophytic Fungus Isolated from Alibertia macrophylla

Author(s):Show less -

de Oliveira, Camila Martins ^[1] ; Silva, Geraldo Humberto ^[2] ; Regasini, Luis Octavio ^[1] ; Flausino, Jr., Otavio ^[1] ; Noeli Lopez, Silvia ^[3] ; Abissi, Barbara Marcondes ^[1] ; de Souza Berlinck, Roberto Gomes ^[4] ; Sette, Lara Duraes ^[5] ; Bonugli-Santos, Rafaella Costa ^[5] ; Rodrigues, Andre ^[6] ; Bolzani, Vanderlan da Silva ^[1] ; Araujo, Angela Regina ^[1]

Affiliation

^[1] Univ Estadual Paulista, Inst Quim, Dept Quim Organ, NuBBE, Nucl Bioensaios Biossintese & Ecofisiol Pro, Sao Paulo - Brazil

^[2] Univ Fed Sergipe, Dept Quim, SN, Itabaiana, Sergipe - Brazil

^[3] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, RA-2000 Rosario, Santa Fe - Argentina

^[4] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

^[5] Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, Div Recursos Microbianos, Sao Paulo - Brazil

^[6] Univ Estadual Sao Paulo, Ctr Estudos Insetos Sociais, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Natural Products; v. 74, n. 6, p. 1353-1357, JUN 2011.
• Web of Science Citations: 9

Abstract

Xylarenones C-E (2-4), three new eremophilane sesquiterpenes, have been isolated from solid substrate cultures of a Camarops-like endophytic fungus isolated from Alibertia macrophylla. The structures were elucidated by analysis of spectroscopic data. Compounds were evaluated in subtilisin and pepsin protease assays, and compound 2 showed potent inhibitory activity against both proteases. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants